Mitogen‑activated protein kinase (MAPK) cascades are key signalling pathways that
regulate a wide variety of cellular processes, including proliferation, differentiation …

The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway
is activated by upstream genomic events and/or activation of multiple signaling events in …

Objective: To develop evidence-based recommendations for safe, effective, and appropriate
thyroidectomy. Background: Surgical management of thyroid disease has evolved …

PURPOSE: Detection of specific molecular alterations in tumors guides the selection of
effective targeted treatment of patients with several types of cancer. These molecular …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid
cancer is becoming increasingly prevalent. Since the American Thyroid Association's …

BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive
Papillary Thyroid Cancer With Highest Recurrence - PMC Back to Top Skip to main content NIH …

Association Between BRAF V600E Mutation and Recurrence of Papillary Thyroid Cancer -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Background About half of patients with papillary thyroid cancer have tumours with activating
BRAF V600E mutations. Vemurafenib, an oncogenic BRAF kinase inhibitor approved for …

BACKGROUND Fine‐needle aspiration (FNA) cytology is a common approach to evaluating
thyroid nodules, although 20% to 30% of FNAs have indeterminate cytology, which hampers …