HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta …

RK Gupta, J Gregson, N Parkin… - The Lancet infectious …, 2018 - thelancet.com
Background Pretreatment drug resistance in people initiating or re-initiating antiretroviral
therapy (ART) containing non-nucleoside reverse transcriptase inhibitors (NNRTIs) might …

Advances in developing CAR T-cell therapy for HIV cure

J Qi, C Ding, X Jiang, Y Gao - Frontiers in Immunology, 2020 - frontiersin.org
Acquired immune deficiency syndrome (AIDS), which is caused by HIV infection, is an
epidemic disease that has killed millions of people in the last several decades. Although …

High viral suppression and detection of dolutegravir-resistance associated mutations in treatment-experienced Tanzanian adults living with HIV-1 in Dar es Salaam

GM Bwire, BG Aiko, IH Mosha, MS Kilapilo… - Scientific Reports, 2023 - nature.com
To curb HIV infection rate in Tanzania, antiretroviral therapy (ART) has been scaled up since
2006, and in 2019, the country shifted to regimen including dolutegravir as a default first line …

Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research

J Dorward, R Lessells, PK Drain, K Naidoo… - The lancet HIV, 2018 - thelancet.com
A new first-line antiretroviral therapy (ART) regimen containing dolutegravir is being rolled
out in low-income and middle-income countries (LMICs). In studies from predominantly high …

[图书][B] Global action plan on HIV drug resistance 2017–2021

World Health Organization - 2017 - apps.who.int
The Global Action Plan on HIV drug resistance (HIVDR) builds on the new global
commitment of the 2030 Agenda for Sustainable Development to end the AIDS epidemic by …

The impact of HIV-1 drug escape on the global treatment landscape

DA Collier, C Monit, RK Gupta - Cell host & microbe, 2019 - cell.com
The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in
combating the HIV epidemic and compromise the 90-90-90 target proposed by United …

Effectiveness of protease inhibitor/nucleos (t) ide reverse transcriptase inhibitor–based second-line antiretroviral therapy for the treatment of human immunodeficiency …

AJ Stockdale, MJ Saunders, MA Boyd… - Clinical infectious …, 2018 - academic.oup.com
Abstract Background In sub-Saharan Africa, 25.5 million people are living with human
immunodeficiency virus (HIV), representing 70% of the global total. The need for second-line …

Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub …

J Gregson, P Kaleebu, VC Marconi… - The Lancet infectious …, 2017 - thelancet.com
Background HIV-1 drug resistance to older thymidine analogue nucleoside reverse
transcriptase inhibitor drugs has been identified in sub-Saharan Africa in patients with …

Simplifying switch to second-line antiretroviral therapy in sub Saharan Africa: predicted effect of using a single viral load to define efavirenz-based first-line failure

A Shroufi, G Van Cutsem, V Cambiano… - Aids, 2019 - journals.lww.com
Background: Many individuals failing first-line antiretroviral therapy (ART) in sub-Saharan
Africa never initiate second-line ART or do so after significant delay. For people on ART with …

Adoption of routine virologic testing and predictors of virologic failure among HIV-infected children on antiretroviral treatment in western Kenya

J Kadima, E Patterson, M Mburu, C Blat, M Nyanduko… - PloS one, 2018 - journals.plos.org
Background Access to routine virologic monitoring, critical to ensuring treatment success,
remains limited in low-and middle-income countries. We report on implementation of routine …