Heart failure is the leading cause of death worldwide, and current therapies only delay
progression of the disease. Laboratory experiments and recent clinical trials suggest that …

Many cell populations, derived from both adult tissues and embryonic stem cells, show
promise for the treatment of a variety of diseases. Although the major effort in stem cell …

Background—Phase I clinical studies have demonstrated the feasibility of implanting
autologous skeletal myoblasts in postinfarction scars. However, they have failed to …

Background Wnt/β-catenin signaling is an important regulator of differentiation and
morphogenesis that can also control stem cell fates. Our group has developed an efficient …

Adult skeletal muscle contains an abundant and highly accessible population of muscle
stem and progenitor cells called satellite cells. The primary function of satellite cells is to …

Randomized, controlled clinical trials have demonstrated that cell therapy can improve the
recovery of cardiac function in patients after acute myocardial infarction (AMI). Trial results …

Heart failure initiated by coronary artery disease and myocardial infarction (MI) is a
widespread, debilitating condition for which there are a limited number of options to prevent …

Transplantation of stem cells into the heart can improve cardiac function after myocardial
infarction and in chronic heart failure, but the extent of benefit and of reproducibility of this …

Stem or progenitor cell–based strategies to combat ischemic heart disease and myocardial
infarction, whether autologous transplantation or stimulation of resident populations, not only …

During post-natal maturation of the mammalian heart, proliferation of cardiomyocytes
essentially ceases as cardiomyocytes withdraw from the cell cycle and develop blocks at the …