Stem-cell therapy for cardiac disease
VFM Segers, RT Lee - Nature, 2008 - nature.com
Heart failure is the leading cause of death worldwide, and current therapies only delay
progression of the disease. Laboratory experiments and recent clinical trials suggest that …
progression of the disease. Laboratory experiments and recent clinical trials suggest that …
Cell delivery mechanisms for tissue repair
DJ Mooney, H Vandenburgh - Cell stem cell, 2008 - cell.com
Many cell populations, derived from both adult tissues and embryonic stem cells, show
promise for the treatment of a variety of diseases. Although the major effort in stem cell …
promise for the treatment of a variety of diseases. Although the major effort in stem cell …
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation
P Menasché, O Alfieri, S Janssens, W McKenna… - Circulation, 2008 - Am Heart Assoc
Background—Phase I clinical studies have demonstrated the feasibility of implanting
autologous skeletal myoblasts in postinfarction scars. However, they have failed to …
autologous skeletal myoblasts in postinfarction scars. However, they have failed to …
Endogenous Wnt/β-catenin signaling is required for cardiac differentiation in human embryonic stem cells
SL Paige, T Osugi, OK Afanasiev, L Pabon… - PloS one, 2010 - journals.plos.org
Background Wnt/β-catenin signaling is an important regulator of differentiation and
morphogenesis that can also control stem cell fates. Our group has developed an efficient …
morphogenesis that can also control stem cell fates. Our group has developed an efficient …
The emerging biology of satellite cells and their therapeutic potential
S Kuang, MA Rudnicki - Trends in molecular medicine, 2008 - cell.com
Adult skeletal muscle contains an abundant and highly accessible population of muscle
stem and progenitor cells called satellite cells. The primary function of satellite cells is to …
stem and progenitor cells called satellite cells. The primary function of satellite cells is to …
Cell therapy for the treatment of coronary heart disease: a critical appraisal
KC Wollert, H Drexler - Nature Reviews Cardiology, 2010 - nature.com
Randomized, controlled clinical trials have demonstrated that cell therapy can improve the
recovery of cardiac function in patients after acute myocardial infarction (AMI). Trial results …
recovery of cardiac function in patients after acute myocardial infarction (AMI). Trial results …
Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges
DM Nelson, Z Ma, KL Fujimoto, R Hashizume… - Acta biomaterialia, 2011 - Elsevier
Heart failure initiated by coronary artery disease and myocardial infarction (MI) is a
widespread, debilitating condition for which there are a limited number of options to prevent …
widespread, debilitating condition for which there are a limited number of options to prevent …
Biomaterials to enhance stem cell function in the heart
VFM Segers, RT Lee - Circulation research, 2011 - Am Heart Assoc
Transplantation of stem cells into the heart can improve cardiac function after myocardial
infarction and in chronic heart failure, but the extent of benefit and of reproducibility of this …
infarction and in chronic heart failure, but the extent of benefit and of reproducibility of this …
Cardiomyocyte death and renewal in the normal and diseased heart
LM Buja, D Vela - Cardiovascular Pathology, 2008 - Elsevier
During post-natal maturation of the mammalian heart, proliferation of cardiomyocytes
essentially ceases as cardiomyocytes withdraw from the cell cycle and develop blocks at the …
essentially ceases as cardiomyocytes withdraw from the cell cycle and develop blocks at the …