The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …

Background Oxaliplatin resistance is a major challenge for treatment of advanced colorectal
cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed …

Objective: To review preclinical and clinical data for oxaliplatin in the current context of
molecularly targeted therapy. Methods of Study Selection: We searched the PubMed and …

Simple Summary Despite remarkable progress being made by preventive medical check-
ups in the last decades, colorectal cancer (CRC) remains one of the most frequent and …

The mitochondrial dysfunction has a critical role in several disorders including
chemotherapy-induced peripheral neuropathies (CIPN). This is due to a related …

Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of …

Simple Summary Cisplatin is successfully used for the treatment of various solid cancers.
Unfortunately, it shows no activity in colorectal cancer. The resistance phenotype of …

Over the last 10 years there has been an explosion of information about the molecular
biology of cancer. A challenge in oncology is to translate this information into advances in …

This study aims to design a pH-responsive dual-loaded nanosystem based on PEGylated
chitosan nanoparticles loaded with ascorbic acid (AA) and oxaliplatin (OX) for the effective …