[HTML][HTML] Polyunsaturated fatty acids drive lipid peroxidation during ferroptosis

MS Mortensen, J Ruiz, JL Watts - Cells, 2023 - mdpi.com
Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In
the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has …

Ferroptosis: Potential opportunities for natural products in cancer therapy

A Nie, C Shen, Z Zhou, J Wang, B Sun… - Phytotherapy …, 2024 - Wiley Online Library
Cancer cells often exhibit defects in the execution of cell death, resulting in poor clinical
outcomes for patients with many cancer types. Ferroptosis is a newly discovered form of …

Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury

J Mann, E Reznik, M Santer, MA Fongheiser… - Cell chemical …, 2024 - cell.com
Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity
whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis …

[HTML][HTML] Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid supplementation

OK Favor, LD Rajasinghe, KA Wierenga… - Frontiers in …, 2023 - frontiersin.org
Introduction Phagocytosis of inhaled crystalline silica (cSiO2) particles by tissue-resident
alveolar macrophages (AMs) initiates generation of proinflammatory eicosanoids derived …

[HTML][HTML] Poly-Unsaturated Fatty Acids (PUFAs) from Cunninghamella elegans Grown on Glycerol Induce Cell Death and Increase Intracellular Reactive Oxygen …

G Kalampounias, C Gardeli, S Alexis… - Journal of Fungi, 2024 - mdpi.com
Cunninghamella elegans NRRL-1393 is an oleaginous fungus able to synthesize and
accumulate unsaturated fatty acids, amongst which the bioactive gamma-linolenic acid …

[HTML][HTML] Exosomes drive ferroptosis by stimulating iron accumulation to inhibit bacterial infection in crustaceans

Q Sun, J Yang, M Zhang, Y Zhang, H Ma… - Journal of Biological …, 2023 - ASBMB
Ferroptosis, characterized by iron-dependent cell death, has recently emerged as a critical
defense mechanism against microbial infections. The present study aims to investigate the …

ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous cell carcinoma cells through m6A-dependent modification

L Huang, G Chen, J He, P Wang - Tissue and Cell, 2023 - Elsevier
Laryngeal squamous cell carcinoma (LSCC) is the second most common head and neck
cancer. To identify the link between ferroptosis and LSCC, we targeted the dual oxidase 1 …

[HTML][HTML] Lipid peroxidation via regulating the metabolism of docosahexaenoic acid and arachidonic acid in autistic behavioral symptoms

K Yui, G Imataka, T Shiohama - Current Issues in Molecular Biology, 2023 - mdpi.com
The association between the lipid peroxidation product malondialdehyde (MDA)-modified
low-density lipoprotein (MDA-LDL) and the pathophysiology of autism spectrum disorder …

[PDF][PDF] Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis. Cells 2023, 12, 804

MS Mortensen, J Ruiz, JL Watts - 2023 - academia.edu
Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In
the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has …

[HTML][HTML] Quantitative Profiling Method for Oxylipins in Neurodegenerative Diseases by Liquid Chromatography Coupled with Tandem Mass Spectrometry

E Pourmand, F Zhang, M Sarparast, JK Alan, KSS Lee - bioRxiv, 2023 - ncbi.nlm.nih.gov
Aging is one of the major risk factors for many chronic diseases, including diabetes,
neuropathy, hypertension, cancer, and neurodegenerative diseases. However, the …