Sequence based T-cell epitope predictions have improved immensely in the last decade.
From predictions of peptide binding to major histocompatibility complex molecules with …

Most protein therapeutics have the potential to induce undesirable immune responses in
patients. Many patients develop anti-therapeutic antibodies, which can affect the safety and …

A large volume of data relevant to immunology research has accumulated due to
sequencing of genomes of the human and other model organisms. At the same time, huge …

As major histocompatibility complexes in humans, the human leukocyte antigens (HLAs)
have important functions to present antigen peptides onto T-cell receptors for immunological …

T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for
cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the …

Motivation: In silico methods for the prediction of antigenic peptides binding to MHC class I
molecules play an increasingly important role in the identification of T-cell epitopes …

Background The binding between antigenic peptides (epitopes) and the MHC molecule is a
key step in the cellular immune response. Accurate in silico prediction of epitope-MHC …

Most therapeutic proteins in clinical trials or on the market are, to a variable extent,
immunogenic. Formation of antidrug antibodies poses a risk that should be assessed during …

The RV144 HIV-1 vaccine trial demonstrated partial efficacy of 31% against HIV-1 infection.
Studies into possible correlates of protection found that antibodies specific to the V1 and V2 …

Motivation: MHC: peptide binding plays a central role in activating the immune surveillance.
Computational approaches to determine T-cell epitopes restricted to any given major …