Computational design of protein therapeutics
Computation is increasingly used to guide protein therapeutic designs. Some of the potential
applications for computational, structure-based protein design include antibody affinity …
applications for computational, structure-based protein design include antibody affinity …
A pan-specific GRU-based recurrent neural network for predicting HLA-I-binding peptides
Y Heng, Z Kuang, S Huang, L Chen, T Shi, L Xu… - ACS …, 2020 - ACS Publications
Human leukocyte antigens (HLAs) play a critical role in human-acquired immune responses
by the recognition of non-self-peptides derived from exogenous bacteria, fungi, virus, and so …
by the recognition of non-self-peptides derived from exogenous bacteria, fungi, virus, and so …
[HTML][HTML] Design of a predicted MHC restricted short peptide immunodiagnostic and vaccine candidate for Fowl adenovirus C in chicken infection
Fowl adenoviruses (FAdVs) are the ethiologic agents of multiple pathologies in chicken.
There are five different species of FAdVs grouped as FAdV-A, FAdV-B, FAdV-C, FAdV-D …
There are five different species of FAdVs grouped as FAdV-A, FAdV-B, FAdV-C, FAdV-D …
Designing of epitope-focused vaccine by targeting E6 and E7 conserved protein sequences: An immuno-informatics approach in human papillomavirus 58 isolates
Human papillomavirus (HPV) is a DNA virus that belongs to the papillomavirus family and is
capable of infecting humans. Currently, few vaccines are available to prevent infection by …
capable of infecting humans. Currently, few vaccines are available to prevent infection by …
Molecular interaction predictors
N Jojic, MJR Gomez - US Patent 7,894,995, 2011 - Google Patents
Adaptive threading models for predicting an interaction between two or more molecules
such as proteins are pro vided. The adaptive threading models have one or more learn able …
such as proteins are pro vided. The adaptive threading models have one or more learn able …
Oncolytic adenoviruses with mutations in immunodominant adenovirus epitopes and their use in cancer treatment
R Alemany, R Gil, M Bazan - US Patent 11,000,560, 2021 - Google Patents
US11000560B2 - Oncolytic adenoviruses with mutations in immunodominant adenovirus
epitopes and their use in cancer treatment - Google Patents US11000560B2 - Oncolytic …
epitopes and their use in cancer treatment - Google Patents US11000560B2 - Oncolytic …
Towards in silico design of epitope-based vaccines
NC Toussaint, O Kohlbacher - Expert Opinion on Drug Discovery, 2009 - Taylor & Francis
Background: Epitope-based vaccines (EVs) make use of immunogenic peptides (epitopes)
to trigger an immune response. Due to their manifold advantages, EVs have recently been …
to trigger an immune response. Due to their manifold advantages, EVs have recently been …
Variable selection through correlation sifting
Many applications of computational biology require a variable selection procedure to sift
through a large number of input variables and select some smaller number that influence a …
through a large number of input variables and select some smaller number that influence a …
Quantitative prediction of class I MHC/epitope binding affinity using QSAR modeling derived from amino acid structural information
Y Wang, P Zhou, Y Lin, M Shu, Y Hu… - … chemistry & high …, 2015 - ingentaconnect.com
The activation of T cell immune responses, which relies on peptide antigens transported by
TAP and bound to major histocompatibility complex (MHC) molecules, is recognized by T …
TAP and bound to major histocompatibility complex (MHC) molecules, is recognized by T …
Improved pan‐specific MHC class I peptide‐binding predictions using a novel representation of the MHC‐binding cleft environment
Major histocompatibility complex (MHC) molecules play a key role in cell‐mediated immune
responses presenting bounded peptides for recognition by the immune system cells …
responses presenting bounded peptides for recognition by the immune system cells …