Harmine is isolated from the seeds of the medicinal plant, Peganum harmala L., and has
been used for thousands of years in the Middle East and China. Harmine has many …

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …

Ethnopharmacological relevance The plants of the genus Peganum have a long history as a
Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma …

Plant secondary metabolites (SMs) common natural occurrences and the significantly lower
toxicities of many SM have led to the approaching development and use of these …

Amphiphilic macrocycles, such as p-sulfonatocalix [6] arenes (p-SC6), have demonstrated
great potential in designing synthetic nanovesicles based on self-assembly approaches …

DYRK1A has been implicated as an important drug target in various therapeutic areas,
including neurological disorders and oncology. DYRK1A has more recently been shown to …

Harmine (HM) is a β‑carboline alkaloid found in multiple medicinal plants. It has been used
in folk medicine for anticancer therapy; however, the molecular mechanism of HM on human …

Recently, our group identified that harmine is able to induce β-cell proliferation both in vitro
and in vivo, mediated via the DYRK1A-NFAT pathway. Since, harmine suffers from a lack of …

A series of novel harmine derivatives bearing a benzylindine substituent in position-1 of β-
carboline ring were synthesized and evaluated as antitumor agents. The N2-benzylated β …

ABSTRACT DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is
highly expressed in glioma, an aggressive brain tumor, and has been proposed as a …