Neutrophils derive from hematopoietic stem cells (HSCs) with systemic inflammation driving
their activation and differentiation to myeloid progenitors to ensure enhanced myelopoiesis …

Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately
affects women. It is characterised by a broad spectrum of clinical manifestations, however, its …

Diabetic nephropathy (DN) is one of the most common complications of diabetes, and
currently the first end-stage renal disease worldwide. New strategies to treat DN using …

Systemic lupus erythematosus (SLE) is a very complex disease where multiple
immunological pathways can concur in inducing tissue damage. Cytokines are key …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
impaired immune tolerance, resulting in the generation of pathogenic autoantibodies and …

Systemic lupus erythematosus (SLE) is a type of autoimmune disease that damages multiple
organs, including the heart, joints, liver and kidneys. The main characteristics of SLE are the …

Recent progress has highlighted the involvement of a variety of innate and adaptive immune
cells in lupus nephritis. These include activated neutrophils producing extracellular …

The kidneys are life-sustaining organs that are vital to removing waste from our body.
Because of their anatomic position and high blood flow, the kidneys are vulnerable to …

Systemic lupus erythematosus (SLE) features a decreased pool of CD4+ CD25+ Foxp3+ T
regulatory (Treg) cells. We had previously observed NKG2D+ CD4+ T cell expansion in …