The purpose of this work is to identify and synthesize research produced since the second
edition of these Guidelines was published and incorporate new results into revised evidence …

Background Current guidelines for the treatment of adult severe traumatic brain injury (sTBI)
consist of high-quality evidence reports, but they are no longer accompanied by …

Cerebrospinal fluid disorders have a wide-ranging impact on vision, headache, cognition
and a person's quality of life. Due to advances in technology and accessibility, intracranial …

Objectives: To produce a treatment algorithm for the ICU management of infants, children,
and adolescents with severe traumatic brain injury. Data Sources: Studies included in the …

Importance Hyperosmolar agents are cornerstone therapies for pediatric severe traumatic
brain injury. Guideline recommendations for 3% hypertonic saline (HTS) are based on …

Importance Multiple organ dysfunction syndrome (MODS) is a dynamic and heterogeneous
process associated with high morbidity and mortality in critically ill children. Objective To …

Measuring intracranial pressure (ICP) is necessary for the treatment of severe head injury
but measurement systems are highly invasive and introduce risk of infection and …

Background: Mannitol and hypertonic saline are widely used to treat raised intracranial
pressure (ICP) after traumatic brain injury (TBI), but the clinical superiority of one over the …

Background: Mannitol and hypertonic saline (HTS) are effective in reducing intracranial
pressure (ICP) after severe traumatic brain injury (TBI). However, their efficacy on the ICP …

Background: We performed a meta-analysis to evaluate the effect of hypertonic saline
compared to mannitol for the management of elevated intracranial pressure in traumatic …