Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Molecular mimicry between viral antigens and host proteins can produce cross-reacting
antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a …

Cardiovascular diseases (CVDs) such as atherosclerosis, myocardial remodeling,
myocardial ischemia-reperfusion (I/R) injury, heart failure, and oxidative stress are among …

In recent decades, the development of targeted drugs has featured prominently in the
treatment of cancer, which is among the major causes of mortality globally. Triazole-fused …

WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various
cellular processes. While WNT ligands usually signal through their dedicated Frizzled …

Immune cells can protect against tumor progression by killing cancer cells, while aberrant
expression of the immune checkpoint protein PD‐L1 (programmed death ligand 1) in cancer …

Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular
principles governing many important E3-E2 partnerships remain unknown, including those …

The great progresses witnessed in the last decade for the rational design of the graphitic
carbon nitride (gC 3 N 4) have warranted its successful use in applications including …

The endoplasmic reticulum (ER) and mitochondria form a unique subcellular compartment
called mitochondria-associated ER membranes (MAMs). Disruption of MAMs impairs Ca2+ …