The PRDM family has recently spawned considerable interest as it has been implicated in
fundamental aspects of cellular differentiation and exhibits expanding ties to human …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

We report the discovery of GATA2 as a new myelodysplastic syndrome (MDS)-acute myeloid
leukemia (AML) predisposition gene. We found the same, previously unidentified …

Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …

Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …

Deregulated expression of the ecotropic virus integration site 1 (EVI 1) gene is the molecular
hallmark of therapy‐resistant myeloid malignancies bearing chromosomal inv (3)(q21q26· 2) …

The classical role of C-terminal binding protein (CtBP) is that of a global corepressor.
However, its exact mechanism of repression is not known. In this review, we elucidate the …

Ecotropic viral integration site-1 (EVI1) is one of the candidate oncogenes for human acute
myeloid leukemia (AML) with chromosomal alterations at 3q26. High EVI1 expression …

The EVI1 oncogene at human chr 3q26 is rearranged and/or overexpressed in a subset of
acute myeloid leukemias and myelodysplasias. The EVI1 protein is a 135 kDa …

Ecotropic viral integration site-1 (EVI1) is an oncogenic zinc finger transcription factor whose
expression is frequently up-regulated in myeloid leukemia and epithelial cancers. To better …