[HTML][HTML] Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss

K Xu, B Xu, J Gu, X Wang, D Yu, Y Chen - Theranostics, 2023 - ncbi.nlm.nih.gov
Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …

The role of the stria vascularis in neglected otologic disease

JD Johns, SM Adadey, M Hoa - Hearing research, 2023 - Elsevier
The stria vascularis (SV) has been shown to play a critical role in the pathogenesis of many
diseases associated with sensorineural hearing loss (SNHL), including age-related hearing …

[HTML][HTML] The Cousa objective: a long-working distance air objective for multiphoton imaging in vivo

CH Yu, Y Yu, LM Adsit, JT Chang, J Barchini… - Nature …, 2024 - nature.com
Multiphoton microscopy can resolve fluorescent structures and dynamics deep in scattering
tissue and has transformed neural imaging, but applying this technique in vivo can be …

[HTML][HTML] The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification

CJ Buswinka, RT Osgood, RG Simikyan… - Plos …, 2023 - journals.plos.org
Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly
specialized cells subdivided into outer hair cells (OHCs) and inner hair cells (IHCs). Light …

Materials, Structures, and Strategies for Foldable Electroluminescent Devices

ZY Chen, D Yin, J Feng - Advanced Optical Materials, 2023 - Wiley Online Library
Foldable electroluminescent (EL) devices have attracted much attention in recent years. By
folding, 2D EL devices can be transformed to 3D structures, which play an important role in …

[HTML][HTML] Unravelling the mystery inside cells by using single-molecule fluorescence imaging

J Zalejski, J Sun, A Sharma - Journal of Imaging, 2023 - mdpi.com
Live-cell imaging is a powerful technique to study the dynamics and mechanics of various
biological molecules like proteins, organelles, DNA, and RNA. With the rapid evolution of …

Identifying targets to prevent aminoglycoside ototoxicity

J Kim, S Hemachandran, AG Cheng, AJ Ricci - Molecular and Cellular …, 2022 - Elsevier
Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use
carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration …

The multifaceted links between hearing loss and chronic kidney disease

D Greenberg, ND Rosenblum, M Tonelli - Nature Reviews Nephrology, 2024 - nature.com
Hearing loss affects nearly 1.6 billion people and is the third-leading cause of disability
worldwide. Chronic kidney disease (CKD) is also a common condition that is associated with …

Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice

M Zallocchi, S Vijayakumar, J Fleegel… - Science Translational …, 2024 - science.org
Hearing loss is a major health concern in our society, affecting more than 400 million people
worldwide. Among the causes, aminoglycoside therapy can result in permanent hearing loss …

[HTML][HTML] Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity

L Han, Z Wang, D Wang, Z Gao, S Hu… - Frontiers in Cell and …, 2024 - frontiersin.org
Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections,
however, aminoglycosides may cause irreversible hearing loss with a long-term clinical …