A critical review of datasets and computational suites for improving cancer theranostics and biomarker discovery
Cancer has been constantly evolving and so is the research pertaining to cancer diagnosis
and therapeutic regimens. Early detection and specific therapeutics are the key features of …
and therapeutic regimens. Early detection and specific therapeutics are the key features of …
[HTML][HTML] A systems biology approach to identify novel biomarkers in progression from Crohn's disease to colorectal cancer
N Shokrollah, P Samadi, A Jalali… - Asian Pacific Journal …, 2023 - ncbi.nlm.nih.gov
Objective: This study aimed to find the key genes and miRNAs as potential biomarkers
related to the progression of colorectal cancer (CRC) from Crohn's disease (CD) …
related to the progression of colorectal cancer (CRC) from Crohn's disease (CD) …
A comprehensive review of 3D cancer models for drug screening and translational research
K Sharma, S Dey, R Karmakar… - Cancer Innovation, 2024 - Wiley Online Library
The 3D cancer models fill the discovery gap of 2D cancer models and play an important role
in cancer research. In addition to cancer cells, a range of other factors include the stroma …
in cancer research. In addition to cancer cells, a range of other factors include the stroma …
[HTML][HTML] In silico identification and clinical validation of a novel long non-coding RNA/mRNA/miRNA molecular network for potential biomarkers for discriminating …
(1) Background: The coronavirus (COVID-19) pandemic is still a major global health
problem, despite the development of several vaccines and diagnostic assays. Moreover, the …
problem, despite the development of several vaccines and diagnostic assays. Moreover, the …
Screening and identification of CNIH4 gene associated with cell proliferation in gastric cancer based on a large-scale CRISPR-Cas9 screening database DepMap
H Zhang, Y Lin, M Zhuang, L Zhu, Y Dai, M Lin - Gene, 2023 - Elsevier
Background Gastric cancer is a common malignant tumor of digestive tract. The study aimed
to identify candidate genes associated with the proliferation and survival of gastric cancer …
to identify candidate genes associated with the proliferation and survival of gastric cancer …
[HTML][HTML] LncRNA HAR1A suppresses the development of non-small cell lung cancer by inactivating the STAT3 pathway
J Ma, K Cao, X Ling, P Zhang, J Zhu - Cancers, 2022 - mdpi.com
Simple Summary We found that lncRNA Highly Accelerated Region 1A (HAR1A) was down
regulated in NSCLC. Moreover, a 23-gene signature derived from HAR1A-related cancer …
regulated in NSCLC. Moreover, a 23-gene signature derived from HAR1A-related cancer …
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β‐catenin signaling pathway
J Zhu, K Cao, P Zhang, J Ma - Cancer Medicine, 2023 - Wiley Online Library
Lung cancer poses severe threats to human health. It is indispensable to discover more
druggable molecular targets. We identified a novel dysregulated long non‐coding RNA …
druggable molecular targets. We identified a novel dysregulated long non‐coding RNA …
[PDF][PDF] Novel molecular classification and prognosis of papillary renal cell carcinoma based on a large-scale CRISPR-Cas9 screening and machine learning
C Liu, ZY Yuan, XX Zhang, JJ Chang, Y Yang, SJ Sun… - Heliyon, 2023 - cell.com
Papillary renal cell carcinoma (PRCC) is a highly heterogeneous cancer, and PRCC
patients with advanced/metastatic subgroup showed obviously shorter survival compared to …
patients with advanced/metastatic subgroup showed obviously shorter survival compared to …
[HTML][HTML] Comprehensive analysis of the significance of METTL7A gene in the prognosis of lung adenocarcinoma
YQ Pan, Y Xiao, Z Li, L Tao, G Chen, JF Zhu… - Frontiers in …, 2022 - frontiersin.org
Background The most common subtype of lung cancer, called lung adenocarcinoma
(LUAD), is also the largest cause of cancer death in the world. The aim of this study was to …
(LUAD), is also the largest cause of cancer death in the world. The aim of this study was to …
[HTML][HTML] Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1
J Zhu, K Cao, M Zhao, K Ma, X Jiang, Y Bai, X Ling… - Molecular …, 2023 - Springer
Abstract Background Activated Cdc42-associated kinase 1 (ACK1) is a promising druggable
target for cancer, but its inhibitors only showed moderate effects in clinical trials. The study …
target for cancer, but its inhibitors only showed moderate effects in clinical trials. The study …