[HTML][HTML] The role of cholesterol metabolism in cancer
X Ding, W Zhang, S Li, H Yang - American journal of cancer …, 2019 - ncbi.nlm.nih.gov
Cholesterol plays an important role in cancer development. Both clinical and experimental
studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect …
studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect …
[HTML][HTML] Pleiotropic effects of statins: A focus on cancer
Abstract The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …
Cardioprotection and lifespan extension by the natural polyamine spermidine
T Eisenberg, M Abdellatif, S Schroeder, U Primessnig… - Nature medicine, 2016 - nature.com
Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …
[HTML][HTML] The role of YAP/TAZ activity in cancer metabolic reprogramming
X Zhang, H Zhao, Y Li, D Xia, L Yang, Y Ma, H Li - Molecular cancer, 2018 - Springer
In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy
production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth …
production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth …
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …
Simvastatin increases temozolomide‐induced cell death by targeting the fusion of autophagosomes and lysosomes
Temozolomide (TMZ) is a chemotherapy agent used to treat Grade IV astrocytoma, also
known as glioblastoma (GBM). TMZ treatment causes DNA damage that results in tumor cell …
known as glioblastoma (GBM). TMZ treatment causes DNA damage that results in tumor cell …
Statin use and reduced hepatocellular carcinoma risk in patients with nonalcoholic fatty liver disease
Background & Aims Recent evidence suggests potential clinical benefits of statin in cancer
chemoprevention and treatment. Nonalcoholic fatty liver disease (NAFLD) is expected to …
chemoprevention and treatment. Nonalcoholic fatty liver disease (NAFLD) is expected to …
Dysregulation of cholesterol metabolism in cancer progression
X Liu, M Lv, W Zhang, Q Zhan - Oncogene, 2023 - nature.com
Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …
[HTML][HTML] MIEF2 reprograms lipid metabolism to drive progression of ovarian cancer through ROS/AKT/mTOR signaling pathway
S Zhao, L Cheng, Y Shi, J Li, Q Yun, H Yang - Cell death & disease, 2021 - nature.com
Abstract MIEF2 (mitochondrial elongation factor 2) is one of the key regulators of
mitochondrial fission. Bioinformatics analysis indicated that high expression of MIEF2 …
mitochondrial fission. Bioinformatics analysis indicated that high expression of MIEF2 …
[HTML][HTML] Temozolomide, simvastatin and acetylshikonin combination induces mitochondrial-dependent apoptosis in GBM cells, which is regulated by autophagy
Simple Summary Glioblastoma multiforme (GBM) is a deadly brain tumor. The current
chemotherapy strategies (including using temozolomide (TMZ)) is not very effective for GBM …
chemotherapy strategies (including using temozolomide (TMZ)) is not very effective for GBM …