Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …

Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …

Many clinical isolates of Pseudomonas aeruginosa cause infections that are difficult to
eradicate due to their resistance to a wide variety of antibiotics. Key genetic determinants of …

Pseudomonas aeruginosa, a major cause of nosocomial and chronic infections, is
considered a paradigm of antimicrobial resistance development. However, the evolutionary …

Genome sequencing of bacterial pathogens has advanced our understanding of their
evolution, epidemiology, and response to antibiotic therapy. However, we still have only a …

Life-long bacterial infections in cystic fibrosis (CF) airways constitute an excellent model
both for persistent infections and for microbial adaptive evolution in complex dynamic …

Pseudomonas aeruginosa airway infections are a major cause of mortality and morbidity of
cystic fibrosis (CF) patients. In order to persist, P. aeruginosa depends on acquiring iron from …

Abstract The Cystic Fibrosis (CF) lung harbors a complex, polymicrobial ecosystem, in which
Pseudomonas aeruginosa is capable of sustaining chronic infections, which are highly …

Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …