Background: Multi-arm multi-stage trials are an efficient, adaptive approach for testing many
treatments simultaneously within one protocol. In settings where numbers of patients …

Background: Previous studies have demonstrated a high risk of arterial and venous
thromboembolic events as a consequence of direct viral damage to endothelial cells by …

Efficient clinical trial designs are needed to speed up the evaluation of new therapies. The
multi-arm multi-stage (MAMS) randomized clinical trial designs have been proposed to …

Objetivo: A infecção causada pelo coronavírus da síndrome respiratória aguda grave 2
(SARS-CoV-2) disseminou-se por todo o mundo e foi categorizada como pandemia. As …

Background Multi-arm multi-stage (MAMS) randomised trial designs have been proposed to
evaluate multiple research questions in the confirmatory setting. In designs with several …

Royston et al.'s (2011, Trials 12: 81) multiarm, multistage (MAMS) framework for the design
of randomized clinical trials uses intermediate outcomes to drop research arms early for lack …

There is a growing need to evaluate of multiple competing drugs in phase II trials where the
number of patients is often limited, and simultaneous assessment of both efficacy and …

Introduction Presently, there are few population-level strategies to address SARS-CoV-2
infection except preventive measures such as vaccination. Micronutrient deficiency …

Background: Despite the need for targeting specific therapeutic options for coronavirus
disease 2019 (COVID-19), there has been no evidence of effectiveness of any specific …

Fundamento Apesar da necessidade de opções terapêuticas específicas para a doença do
coronavírus 2019 (covid-19), ainda não há evidências da eficácia de tratamentos …