Mitochondrial quality control in cerebral ischemia–reperfusion injury

M Wu, X Gu, Z Ma - Molecular Neurobiology, 2021 - Springer
Ischemic stroke is one of the leading causes of death and also a major cause of adult
disability worldwide. Revascularization via reperfusion therapy is currently a standard …

Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed

AM Bețiu, L Noveanu, IM Hâncu, A Lascu… - International Journal of …, 2022 - mdpi.com
Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

Irisin Rescues Blood‐Brain Barrier Permeability following Traumatic Brain Injury and Contributes to the Neuroprotection of Exercise in Traumatic Brain Injury

P Guo, Z Jin, J Wang, A Sang… - Oxidative medicine and …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) has a high incidence, mortality, and morbidity all over the world.
One important reason for its poor clinical prognosis is brain edema caused by blood‐brain …

[HTML][HTML] Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt …

L Liu, Q Cao, W Gao, B Li, Z Xia, B Zhao - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and
have a worse prognosis and higher mortality after ischemic stroke than non-diabetic …

Verapamil alleviates myocardial ischemia/reperfusion injury by attenuating oxidative stress via activation of SIRT1

M Bao, W Huang, Y Zhao, X Fang, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Myocardial ischemia/reperfusion (I/R) injury is a potential complication of ischemic heart
disease after recanalization. One of the primary reasons for I/R injury is the excessive …

Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats via activating the Nrf2/ARE signalling pathway

Q Miao, R Wang, X Sun, S Du, L Liu - Pharmaceutical Biology, 2022 - Taylor & Francis
Abstract Context Puerarin (Pue) and tanshinone IIA (Tan IIA) are often used in combination
in the treatment of cerebrovascular diseases. Objective To investigate the neuroprotective …

Verapamil inhibits TXNIP-NLRP3 inflammasome activation and preserves functional recovery after intracerebral hemorrhage in mice

S Ismael, D Patrick, M Salman, A Parveen… - Neurochemistry …, 2022 - Elsevier
Intracerebral hemorrhage (ICH) is the second most common type of stroke with no
satisfactory treatment. Recent studies from our group and others indicated a potential …

Enhanced neuroprotective effect of verapamil-loaded hyaluronic acid modified carbon quantum dots in an in-vitro model of amyloid-induced Alzheimer's disease

EM Mosalam, HM Abdel-Bar, AI Elberri… - International Journal of …, 2024 - Elsevier
This study aims to investigate the molecular mechanisms and the neuroprotective effect of
hyaluronic acid modified verapamil-loaded carbon quantum dots (VRH-loaded HA-CQDs) …

Relevance of mitochondrial oxidative stress to arrhythmias: innovative concepts to target treatments

C Liu, N Ma, Z Guo, Y Zhang, J Zhang, F Yang… - Pharmacological …, 2022 - Elsevier
Cardiac arrhythmia occurs frequently worldwide, and in severe cases can be fatal.
Mitochondria are the power plants of cardiomyocytes. In recent studies, mitochondria under …

Preliminary evaluation of the antiglycoxidant activity of verapamil using various in vitro and in silico biochemical/biophysical methods

M Nesterowicz, KK Lauko, K Dańkowska… - Frontiers in …, 2023 - frontiersin.org
Introduction: Glycoxidative stress is essential for linking glucose disturbances and
cardiovascular diseases. Unfortunately, contemporary antidiabetic drugs do not have an …