GLP-1 peptide analogs for targeting pancreatic beta cells

SE Alavi, HE Shahmabadi - Drug Discovery Today, 2021 - Elsevier
Loss or dysfunction of the pancreatic beta cells or insulin receptors leads to diabetes
mellitus (DM). This usually occurs over many years; therefore, the development of methods …

Cisplatin uptake and release assessment from hydrogel synthesized in acidic and neutral medium: An experimental and molecular dynamics simulation study

I Salahshoori, Z Ramezani, I Cacciotti… - Journal of Molecular …, 2021 - Elsevier
Targeted drug delivery systems (TDDS) are currently considered to overcome traditional
drug delivery systems' criticisms and weaknesses. Biodegradable hydrogels are widely …

Nanomaterials for the diagnosis and treatment of head and neck cancers: A review

G Ruiz-Pulido, DI Medina, M Barani, A Rahdar… - Materials, 2021 - mdpi.com
Head and neck cancer (HNC) is a category of cancers that typically arise from the nose-,
mouth-, and throat-lining squamous cells. The later stage of HNC diagnosis significantly …

Development of thiabendazole-loaded mesoporous silica nanoparticles for cancer therapy

MKM Esfahani, N Islam, PJ Cabot… - … Biomaterials Science & …, 2021 - ACS Publications
Thiabendazole (TBZ) is an anthelmintic drug currently studied for anticancer purposes.
However, due to its low solubility, its biomedical application has been limited. Using …

Optimized methods for the production and bioconjugation of site-specific, alkyne-modified glucagon-like peptide-1 (GLP-1) analogs to azide-modified delivery …

SE Alavi, PJ Cabot, GY Yap, PM Moyle - Bioconjugate Chemistry, 2020 - ACS Publications
This study aimed to develop and optimize chemistries to produce alkyne-modified glucagon-
like peptide-1 (7–36)-amide (GLP-1 (7–36)-NH2) libraries, which could be rapidly and …

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

DI Cocoș, O Dumitriu Buzia, AL Tatu, M Dinu… - Pharmaceutics, 2024 - mdpi.com
In this study, we focused on innovative approaches to improve drug administration in oral
pathology, especially by transmucosal and transdermal pathways. These improvements …

A topical gel nanoformulation of amphotericin B (AmB) for the treatment of cutaneous leishmaniasis (CL)

R Boshrouyeh, S Amari… - Journal of Sol-Gel …, 2023 - Springer
This study aimed to improve the water solubility and cutaneous permeability of Amphotericin
B (AmB) for the topical treatment of Leishmania major-induced cutaneous leishmaniasis …

The Synergistic Anticancer Effect of Dual Drug‐(Cisplatin/Epigallocatechin Gallate) Loaded Gelatin Nanoparticles for Lung Cancer Treatment

YJ Chen, ZW Wang, TL Lu, CB Gomez… - Journal of …, 2020 - Wiley Online Library
Lung cancer has the highest mortality of any cancer worldwide, and cisplatin is a first‐line
chemotherapeutic agent for lung cancer treatment. Unfortunately, cisplatin resistance is a …

[HTML][HTML] Enhancing the efficacy of albendazole for liver cancer treatment using mesoporous silica nanoparticles: An in vitro study

M Ghaferi, W Zahra, A Akbarzadeh, HE Shahmabadi… - Excli Journal, 2022 - ncbi.nlm.nih.gov
The present study aimed to synthesize albendazole (ABZ)-loaded Mobil Composition of
Matter No. 41 (MCM-41 NPs) to increase the efficacy of the drug against liver cancer. ABZ …

Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of …

X Chen, T Yin, B Zhang, B Sun… - International …, 2020 - spandidos-publications.com
Breakthroughs in cancer management result from the development of drugs that can be
used for early diagnosis and effective treatment. Surgery, chemotherapy, radiotherapy and …