The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs),
including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK …

The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …

Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK)
cascades is a common mechanism of signal transduction in many cellular processes. Four …

Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well
characterized as mediators of inflammation and neoplastic transformation. Recent work has …

Experimental evidence supported by epidemiological findings suggests that solar ultraviolet
(UV) irradiation is the most important environmental carcinogen leading to the development …

Solar ultraviolet (UV) radiation is an important environmental factor that leads to immune
suppression, inflammation, photoaging, and skin carcinogenesis. Here, we reviewed the …

[Frontiers in Bioscience 13, 4258-4275, May 1, 2008] 4258 The RSK factors of activating the
Ras/MAPK signaling cascade Audrey Ca Page 1 [Frontiers in Bioscience 13, 4258-4275, May …