Immune responses in diverse tissue sites are critical for protective immunity and
homeostasis. Here, we investigate how tissue localization regulates the development and …

Chronic infections promote the terminal differentiation (or" exhaustion") of T cells and are
thought to preclude the formation of memory T cells. In contrast, we discovered a small …

In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …

Immune evasion is a hallmark of cancer and therapies that restore immune surveillance
have proven highly effective in cancers with high tumor mutation burden (TMB)(for example …

T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

T memory stem cells (T SCM) display increased self-renewal and prolonged survival
capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell …

Lactate is a key metabolite produced from glycolytic metabolism of glucose molecules, yet it
also serves as a primary carbon fuel source for many cell types. In the tumor-immune …

During chronic viral infection, virus-specific CD8+ T cells become exhausted, exhibit poor
effector function and lose memory potential,,,. However, exhausted CD8+ T cells can still …