The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
S Gautam, J Fioravanti, W Zhu, JB Le Gall… - Nature …, 2019 - nature.com
Stem cells are maintained by transcriptional programs that promote self-renewal and
repress differentiation. Here, we found that the transcription factor c-Myb was essential for …
repress differentiation. Here, we found that the transcription factor c-Myb was essential for …
[HTML][HTML] Characteristics of TCR repertoire associated with successful immune checkpoint therapy responses
J Kidman, N Principe, M Watson, T Lassmann… - Frontiers in …, 2020 - frontiersin.org
Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint
therapy (ICT) leads to durable responses in some patients with some cancers. However, the …
therapy (ICT) leads to durable responses in some patients with some cancers. However, the …
Transcriptional regulation of tissue-resident lymphocytes
Numerous innate and adaptive immune cells reside in non-lymphoid tissues, where they
contribute to barrier immunity, tissue homeostasis, and immune regulation. These tissue …
contribute to barrier immunity, tissue homeostasis, and immune regulation. These tissue …
Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy
Stem-like CD8+ T cells are regulated by T cell factor 1 (TCF1) and are considered requisite
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …
[HTML][HTML] Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases
D Panigrahy, A Gartung, J Yang… - The Journal of …, 2019 - Am Soc Clin Investig
Cancer therapy is a double-edged sword, as surgery and chemotherapy can induce an
inflammatory/immunosuppressive injury response that promotes dormancy escape and …
inflammatory/immunosuppressive injury response that promotes dormancy escape and …
Therapeutic cancer vaccines: are we there yet?
CA Klebanoff, N Acquavella, Z Yu… - Immunological …, 2011 - Wiley Online Library
Enthusiasm for therapeutic cancer vaccines has been rejuvenated with the recent
completion of several large, randomized phase III clinical trials that in some cases have …
completion of several large, randomized phase III clinical trials that in some cases have …
Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells
Memory CD8+ T cells are critical for host defense upon reexposure to intracellular
pathogens. We found that interleukin 10 (IL-10) derived from CD4+ regulatory T cells (Treg …
pathogens. We found that interleukin 10 (IL-10) derived from CD4+ regulatory T cells (Treg …
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
The developmental origins of memory T cells remain incompletely understood. During the
expansion phase of acute viral infection, we identified a distinct subset of virus-specific …
expansion phase of acute viral infection, we identified a distinct subset of virus-specific …
[PDF][PDF] Suppression of Tcf1 by inflammatory cytokines facilitates effector CD8 T cell differentiation
The formation of central CD8 T cell memory in response to infection depends on the
transcription factor Tcf1 (Tcf7). Tcf1 is expressed at high levels in naive CD8 T cells but …
transcription factor Tcf1 (Tcf7). Tcf1 is expressed at high levels in naive CD8 T cells but …
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains
The immunostimulatory intracellular domains (ICDs) of chimaeric antigen receptors (CARs)
are essential for converting antigen recognition into antitumoural function. Although there …
are essential for converting antigen recognition into antitumoural function. Although there …