T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

A microglial cell is both a glial cell of the central nervous system and a mononuclear
phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and …

Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of
multiple sclerosis. However, the initial triggers that activate innate immune responses and …

The NLRP3 inflammasome is a multiprotein complex consisting of three kinds of proteins,
NLRP3, ASC, and pro-caspase-1, and plays a role in sensing pathogens and danger …

Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

Natural killer (NK) cells are bone marrow–derived granular lymphocytes that have a key role
in immune defense against viral and bacterial infections and malignancies. NK cells are …

Multiple sclerosis (MS) is an autoimmune disorder characterized by demyelination and
neurodegeneration in the central nervous system (CNS); severe symptoms lead MS patients …

Pro-inflammatory CD4+ T helper (Th) cells drive the pathogenesis of many autoimmune
conditions. Recent advances have modified views of the phenotype of pro-inflammatory Th …

Understanding and treatment of spinal cord pathology is limited in part by a lack of time-
lapse in vivo imaging strategies at the cellular level. We developed a chronically implanted …

Abstract The C–X–C motif ligand 16, or CXCL16, is a chemokine that belongs to the ELR−
CXC subfamily. Its function is to bind to the chemokine receptor CXCR6, which is a G protein …