Flow-mediated endothelial mechanotransduction
PF Davies - Physiological reviews, 1995 - journals.physiology.org
Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …
vascular tone, the regulation of arterial structure and remodeling, and the localization of …
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
P Angel, M Karin - Biochimica et Biophysica Acta (BBA)-Reviews on …, 1991 - Elsevier
Activator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is …
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is …
The regulation and function of c-fos and other immediate early genes in the nervous system
M Sheng, ME Greenberg - Neuron, 1990 - Elsevier
The unique morphological and excitable properties of nerve cells endow them with
specialized properties that permit the reception, transmission, and storage of information. It …
specialized properties that permit the reception, transmission, and storage of information. It …
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation
Networks of protein interactions coordinate cellular functions. We describe a bimolecular
fluorescence complementation (BiFC) assay for determination of the locations of protein …
fluorescence complementation (BiFC) assay for determination of the locations of protein …
A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants
PB Harbury, T Zhang, PS Kim, T Alber - Science, 1993 - science.org
Coiled-coil sequences in proteins consist of heptad repeats containing two characteristic
hydrophobic positions. The role of these buried hydrophobic residues in determining the …
hydrophobic positions. The role of these buried hydrophobic residues in determining the …
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
T Hai, T Curran - Proceedings of the national academy of …, 1991 - National Acad Sciences
The Fos/Jun and ATF/CREB families of transcription factors function in coupling extracellular
signals to alterations in expression of specific target genes. Like many eukaryotic …
signals to alterations in expression of specific target genes. Like many eukaryotic …
The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α helices: crystal structure of the protein-DNA complex
The yeast transcriptional activator GCN4 is 1 of over 30 identified eukaryotic proteins
containing the basic region leucine zipper (bZIP) DNA-binding motif. We have determined …
containing the basic region leucine zipper (bZIP) DNA-binding motif. We have determined …
Redox regulation of fos and jun DNA-binding activity in vitro
C Abate, L Patel, FJ Rauscher III, T Curran - Science, 1990 - science.org
The proto-oncogenes c-fos and c-jun function cooperatively as inducible transcription factors
in signal transduction processes. Their protein products, Fos and Jun, form a heterodimeric …
in signal transduction processes. Their protein products, Fos and Jun, form a heterodimeric …
Crystal structure of the heterodimeric bZIP transcription factor c-Fos–c-Jun bound to DNA
JNM Glover, SC Harrison - Nature, 1995 - nature.com
THE Fos and Jun families of eukaryotic transcription factors heterodimerize to form
complexes capable of binding 5'-TGAGTCA-3'DNA elements. We have determined the X-ray …
complexes capable of binding 5'-TGAGTCA-3'DNA elements. We have determined the X-ray …
Oncogenic activity of the c-Myc protein requires dimerization with Max
Summary c-Myc (Myc) and Max proteins dimerize and bind DNA through basic-helix-loop-
helix-leucine zipper motifs (b-HLH-LZ). Using a genetic approach, we demonstrate that …
helix-leucine zipper motifs (b-HLH-LZ). Using a genetic approach, we demonstrate that …