Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity

AS Widge - Neuropsychopharmacology, 2024 - nature.com
Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …

Oscillotherapeutics–Time-targeted interventions in epilepsy and beyond

Y Takeuchi, A Berényi - Neuroscience Research, 2020 - Elsevier
Oscillatory brain activities support many physiological functions from motor control to
cognition. Disruptions of the normal oscillatory brain activities are commonly observed in …

[HTML][HTML] Brain stimulation competes with ongoing oscillations for control of spike timing in the primate brain

MR Krause, PG Vieira, JP Thivierge, CC Pack - PLoS biology, 2022 - journals.plos.org
Transcranial alternating current stimulation (tACS) is a popular method for modulating brain
activity noninvasively. In particular, tACS is often used as a targeted intervention that …

[HTML][HTML] The phase of sensorimotor mu and beta oscillations has the opposite effect on corticospinal excitability

M Wischnewski, ZJ Haigh, S Shirinpour, I Alekseichuk… - Brain stimulation, 2022 - Elsevier
Background Neural oscillations in the primary motor cortex (M1) shape corticospinal
excitability. Power and phase of ongoing mu (8–13 Hz) and beta (14–30 Hz) activity may …

[HTML][HTML] Brain oscillation-synchronized stimulation of the left dorsolateral prefrontal cortex in depression using real-time EEG-triggered TMS

B Zrenner, C Zrenner, PC Gordon, P Belardinelli… - Brain stimulation, 2020 - Elsevier
Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral
prefrontal cortex (DLPFC) is an effective treatment for major depressive disorder (MDD), but …

Closed-loop optogenetic control of the dynamics of neural activity in non-human primates

B Zaaimi, M Turnbull, A Hazra, Y Wang… - Nature biomedical …, 2023 - nature.com
Electrical neurostimulation is effective in the treatment of neurological disorders, but
associated recording artefacts generally limit its applications to open-loop stimuli. Real-time …

Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network

H Cagnan, N Mallet, CKE Moll… - Proceedings of the …, 2019 - National Acad Sciences
Beta frequency oscillations (15 to 35 Hz) in cortical and basal ganglia circuits become
abnormally synchronized in Parkinson's disease (PD). How excessive beta oscillations …

[HTML][HTML] Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease

C Wiest, G Tinkhauser, A Pogosyan, M Bange… - Neurobiology of …, 2020 - Elsevier
Local field potentials (LFPs) may afford insight into the mechanisms of action of deep brain
stimulation (DBS) and potential feedback signals for adaptive DBS. In Parkinson's disease …

Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease

S Khawaldeh, G Tinkhauser, F Torrecillos, S He… - Brain, 2022 - academic.oup.com
Exaggerated local field potential bursts of activity at frequencies in the low beta band are a
well-established phenomenon in the subthalamic nucleus of patients with Parkinson's …

[HTML][HTML] Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation

KAM Pauls, O Korsun, J Nenonen, J Nurminen… - NeuroImage, 2022 - Elsevier
Exaggerated subthalamic beta oscillatory activity and increased beta range cortico-
subthalamic synchrony have crystallized as the electrophysiological hallmarks of …