Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …

Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …

We reconstructed the structure of actin filament branch junctions formed by fission yeast
Arp2/3 complex at 3.5 Å resolution from images collected by electron cryo-microscopy …

Significant recent advances in structural biology, particularly in the field of cryoelectron
microscopy, have dramatically expanded our ability to create structural models of proteins …

Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …

The actin-related protein (Arp) 2/3 complex nucleates branched actin filament networks
pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly …

Arp2/3 complex generates branched actin networks that drive fundamental processes such
as cell motility and cytokinesis. The complex comprises seven proteins, including actin …