The next generation of CRISPR–Cas technologies and applications
A Pickar-Oliver, CA Gersbach - Nature reviews Molecular cell biology, 2019 - nature.com
The prokaryote-derived CRISPR–Cas genome editing systems have transformed our ability
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …
[HTML][HTML] Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
H Zhang, C Qin, C An, X Zheng, S Wen, W Chen, X Liu… - Molecular cancer, 2021 - Springer
Abstract The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and
Jennifer Doudna for the development of the Clustered regularly interspaced short …
Jennifer Doudna for the development of the Clustered regularly interspaced short …
[HTML][HTML] Advances in CRISPR therapeutics
The clustered regularly interspaced short palindromic repeats (CRISPR) renaissance was
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
catalysed by the discovery that RNA-guided prokaryotic CRISPR-associated (Cas) proteins …
CRISPR/Cas genome editing and precision plant breeding in agriculture
K Chen, Y Wang, R Zhang, H Zhang… - Annual review of plant …, 2019 - annualreviews.org
Enhanced agricultural production through innovative breeding technology is urgently
needed to increase access to nutritious foods worldwide. Recent advances in CRISPR/Cas …
needed to increase access to nutritious foods worldwide. Recent advances in CRISPR/Cas …
[HTML][HTML] Programmable inhibition and detection of RNA viruses using Cas13
The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA)
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA …
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA …
[HTML][HTML] CRISPR-Cas9: a preclinical and clinical perspective for the treatment of human diseases
G Sharma, AR Sharma, M Bhattacharya, SS Lee… - Molecular Therapy, 2021 - cell.com
At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …
research era. Genome modification studies have traveled a long way from gene …
CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery
Genome editing offers promising solutions to genetic disorders by editing DNA sequences
or modulating gene expression. The clustered regularly interspaced short palindromic …
or modulating gene expression. The clustered regularly interspaced short palindromic …
CRISPR/Cas9 in genome editing and beyond
The Cas9 protein (CRISPR-associated protein 9), derived from type II CRISPR (clustered
regularly interspaced short palindromic repeats) bacterial immune systems, is emerging as a …
regularly interspaced short palindromic repeats) bacterial immune systems, is emerging as a …
[HTML][HTML] Programmable RNA tracking in live cells with CRISPR/Cas9
RNA-programmed genome editing using CRISPR/Cas9 from Streptococcus pyogenes has
enabled rapid and accessible alteration of specific genomic loci in many organisms. A …
enabled rapid and accessible alteration of specific genomic loci in many organisms. A …
[HTML][HTML] CRISPR/Cas9-mediated viral interference in plants
Z Ali, A Abulfaraj, A Idris, S Ali, M Tashkandi… - Genome biology, 2015 - Springer
Abstract Background The CRISPR/Cas9 system provides bacteria and archaea with
molecular immunity against invading phages and conjugative plasmids. Recently …
molecular immunity against invading phages and conjugative plasmids. Recently …