[HTML][HTML] Aspartame—true or false? Narrative review of safety analysis of general use in products

K Czarnecka, A Pilarz, A Rogut, P Maj, J Szymańska… - Nutrients, 2021 - mdpi.com
Aspartame is a sweetener introduced to replace the commonly used sucrose. It was
discovered by James M. Schlatter in 1965. Being 180–200 times sweeter than sucrose, its …

The metabolic syndrome, a human disease

M Alemany - International journal of molecular sciences, 2024 - mdpi.com
This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol

M Yang, J Miao, J Rizak, R Zhai… - Journal of …, 2014 - content.iospress.com
A recently established link between formaldehyde, a methanol metabolite, and Alzheimer's
disease (AD) pathology has provided a new impetus to investigate the chronic effects of …

Alzheimer's disease and methanol toxicity (part 1): chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice

M Yang, J Lu, J Miao, J Rizak, J Yang… - Journal of …, 2014 - content.iospress.com
Although methanol toxicity is well known for acute neurological sequelae leading to
blindness or death, there is a new impetus to investigate the chronic effects of methanol …

Alzheimer's disease-like pathologies and cognitive impairments induced by formaldehyde in non-human primates

R Zhai, J Rizak, NA Zheng, X He, Z Li… - Current Alzheimer …, 2018 - ingentaconnect.com
Background: Formaldehyde (FA) has been implicated in Alzheimer's disease (AD) pathology
as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Aβ) …

A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse

M Qiang, R Xiao, T Su, BB Wu, ZQ Tong… - Journal of …, 2014 - content.iospress.com
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
worldwide. Increasing evidence suggests that formaldehyde might be one of the various …

Evidence for conversion of methanol to formaldehyde in nonhuman primate brain

R Zhai, N Zheng, J Rizak, X Hu - Analytical Cellular Pathology, 2016 - Wiley Online Library
Many studies have reported that methanol toxicity to primates is mainly associated with its
metabolites, formaldehyde (FA) and formic acid. While methanol metabolism and toxicology …

[HTML][HTML] Dietary methanol and autism

RG Walton, WC Monte - Medical hypotheses, 2015 - Elsevier
The authors sought to establish whether maternal dietary methanol during pregnancy was a
factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to …

Is formaldehyde the missing link in AD pathology? The differential aggregation of amyloid-beta with APOE isoforms in vitro

JD Rizak, Y Ma, X Hu - Current Alzheimer Research, 2014 - ingentaconnect.com
Apolipoprotein E (APOE) genetic variation and aging are the two most noted risk factors
associated with the development of Alzheimer's disease (AD) related dementia. However …

Cognitive changes after methanol exposure: Longitudinal perspective

K Bukacova, J Mana, J Klempíř, I Lišková, H Brožová… - Toxicology letters, 2021 - Elsevier
Background From 2012 to 2013, there was a mass methanol poisoning outbreak in the
Czech Republic. Methanol metabolites can cause specific lesions in the basal ganglia …