Macrophages as tools and targets in cancer therapy
A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
A timeline of tumour-associated macrophage biology
L Cassetta, JW Pollard - Nature Reviews Cancer, 2023 - nature.com
Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …
populated by many immune cells, of which macrophages are among the most abundant …
Clinical relevance of tumour-associated macrophages
MJ Pittet, O Michielin, D Migliorini - Nature reviews Clinical oncology, 2022 - nature.com
In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies
N Kumari, SH Choi - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …
Metabolism of tissue macrophages in homeostasis and pathology
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …
anabolism to generate cellular energy and structural components. The emerging field of …
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers
Tumor microenvironments (TMEs) influence cancer progression but are complex and often
differ between patients. Considering that microenvironment variations may reveal rules …
differ between patients. Considering that microenvironment variations may reveal rules …
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer
BG Nixon, F Kuo, LL Ji, M Liu, K Capistrano, M Do… - Immunity, 2022 - cell.com
Tumors are populated by antigen-presenting cells (APCs) including macrophage subsets
with distinct origins and functions. Here, we examined how cancer impacts mononuclear …
with distinct origins and functions. Here, we examined how cancer impacts mononuclear …
The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
D Bruni, HK Angell, J Galon - Nature Reviews Cancer, 2020 - nature.com
Abstract The international American Joint Committee on Cancer/Union for International
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …
Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the …
Inflammation: the incubator of the tumor microenvironment
D Denk, FR Greten - Trends in Cancer, 2022 - cell.com
An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …