The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Only in recent years have we begun to appreciate the involvement of fibroblasts in intestinal
development, tissue homeostasis, and disease. These insights followed the advent of single …

Multiple lines of evidence are indicating that cancer development and malignant
progression are not exclusively epithelial cancer cell-autonomous processes but may also …

Matricellular proteins are involved in the crosstalk between cells and their environment and
thus play an important role in allergic and inflammatory reactions. Periostin, a matricellular …

Matricellular proteins are responsible for regulating the microenvironment, the behaviors of
surrounding cells, and the homeostasis of tissues. Periostin (POSTN), a non-structural …

Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the
view of cancer as a tumor cell-centric disease. The tumor microenvironment, especially …