Delaying and even reversing ageing is a major public health challenge with a tremendous
potential to postpone a plethora of diseases including cancer, metabolic syndromes and …

Abstract Background 27-hydroxycholesterol (HC) and 25-HC were identified as endogenous
selective estrogen receptor modulators (SERMs) and estrogen receptor (ER) modulators …

Objectives Oxysterols, a family of oxidized cholesterol derivates, are of increasing interest
due to their role in cancer development and progression. Some oxysterols are estrogen …

Cholesterol (CHOL) is a multifaceted lipid molecule. It is an essential structural component
of cell membranes, where it cooperates in regulating the intracellular trafficking and …

Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies,
including cancer. In breast cancer, the link is especially strong due to interactions between …

hydroxycholesterol (27‐HC) is a cholesterol metabolite and the first discovered endogenous
selective estrogen receptor modulator (SERM) that has been shown to have proliferative …

Introduction To explore the potential impact of 27-hydroxycholesterol (27-HC) on trophoblast
cell function in pre-eclampsia. Results The levels of 27-HC and the expression of CYP27A1 …

Oxysterols and oxysterol-metabolizing enzymes have been implicated in the pathogenesis
of various cancers. However, the distinct function of the oxysterol-metabolizing enzyme …

Cholesterol is easily oxidized and can be transformed into numerous oxidation products,
among which oxysterols. Phytosterols are plant sterols related to cholesterol. Both oxysterols …

Background: Although several roles of 27-hydroxycholesterol (27-HC), the most abundant
oxysterol in blood circulation, in cancers have been elucidated, its impact on breast cancer …