Urinary mitochondrial DNA copy number identifies chronic renal injury in hypertensive patients

A Eirin, A Saad, H Tang, SM Herrmann, JR Woollard… - …, 2016 - Am Heart Assoc
Mitochondrial injury contributes to renal dysfunction in several models of renal disease, but
its involvement in human hypertension remains unknown. Fragments of the mitochondrial …

Protective down-regulated states in the human brain: A possible lesson from COVID-19

ND Schiff, EN Brown - … of the National Academy of Sciences, 2022 - National Acad Sciences
The COVID-19 pandemic has created a large population of patients who are slow to recover
consciousness following mechanical ventilation and sedation in the intensive care unit. Few …

Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis

S Liu, Y Soong, SV Seshan… - American Journal of …, 2014 - journals.physiology.org
Microvascular rarefaction, or loss of microvascular density, is increasingly implicated in the
progression from acute ischemic kidney injury to chronic kidney disease. Microvascular …

Microvascular dysfunction and kidney disease: Challenges and opportunities?

S Krishnan, AD Suarez‐Martinez, P Bagher… - …, 2021 - Wiley Online Library
Kidneys are highly vascular organs that despite their relatively small size receive 20% of the
cardiac output. The highly intricate, delicately organized structure of renal microcirculation is …

[HTML][HTML] Renal scattered tubular-like cells confer protective effects in the stenotic murine kidney mediated by release of extracellular vesicles

X Zou, SH Kwon, K Jiang, CM Ferguson, AS Puranik… - Scientific reports, 2018 - nature.com
To test the hypothesis that intrinsic renal scattered tubular cells (STC-like cells) contribute to
repairing injured tubular epithelial cells (TEC) by releasing extracellular vesicle (EV). EV …

Stent revascularization restores cortical blood flow and reverses tissue hypoxia in atherosclerotic renal artery stenosis but fails to reverse inflammatory pathways or …

A Saad, SMS Herrmann, J Crane… - Circulation …, 2013 - Am Heart Assoc
Background—Atherosclerotic renal artery stenosis (ARAS) is known to reduce renal blood
flow, glomerular filtration rate (GFR) and amplify kidney hypoxia, but the relationships …

Management of atherosclerotic renovascular disease after Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL)

SMS Herrmann, A Saad… - Nephrology Dialysis …, 2015 - academic.oup.com
Many patients with occlusive atherosclerotic renovascular disease (ARVD) may be
managed effectively with medical therapy for several years without endovascular stenting …

Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension

A Eirin, B Ebrahimi, SH Kwon, JA Fiala… - Journal of the …, 2016 - Am Heart Assoc
Background Renovascular hypertension (RVH) impairs cardiac structure and left ventricular
(LV) function, but whether mitochondrial injury is implicated in RVH‐induced myocardial …

Paradigm shifts in atherosclerotic renovascular disease: where are we now?

SC Textor, LO Lerman - Journal of the American Society of …, 2015 - journals.lww.com
Results of recent clinical trials and experimental studies indicate that whereas
atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue …

[HTML][HTML] Oxidative stress and mitochondrial abnormalities contribute to decreased endothelial nitric oxide synthase expression and renal disease progression in early …

AS Kahveci, TT Barnatan, A Kahveci, AE Adrian… - International journal of …, 2020 - mdpi.com
Vascular abnormalities are the most important non-cystic complications in Polycystic Kidney
Disease (PKD) and contribute to renal disease progression. Endothelial dysfunction and …