Urinary mitochondrial DNA copy number identifies chronic renal injury in hypertensive patients
Mitochondrial injury contributes to renal dysfunction in several models of renal disease, but
its involvement in human hypertension remains unknown. Fragments of the mitochondrial …
its involvement in human hypertension remains unknown. Fragments of the mitochondrial …
Protective down-regulated states in the human brain: A possible lesson from COVID-19
ND Schiff, EN Brown - … of the National Academy of Sciences, 2022 - National Acad Sciences
The COVID-19 pandemic has created a large population of patients who are slow to recover
consciousness following mechanical ventilation and sedation in the intensive care unit. Few …
consciousness following mechanical ventilation and sedation in the intensive care unit. Few …
Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis
S Liu, Y Soong, SV Seshan… - American Journal of …, 2014 - journals.physiology.org
Microvascular rarefaction, or loss of microvascular density, is increasingly implicated in the
progression from acute ischemic kidney injury to chronic kidney disease. Microvascular …
progression from acute ischemic kidney injury to chronic kidney disease. Microvascular …
Microvascular dysfunction and kidney disease: Challenges and opportunities?
S Krishnan, AD Suarez‐Martinez, P Bagher… - …, 2021 - Wiley Online Library
Kidneys are highly vascular organs that despite their relatively small size receive 20% of the
cardiac output. The highly intricate, delicately organized structure of renal microcirculation is …
cardiac output. The highly intricate, delicately organized structure of renal microcirculation is …
[HTML][HTML] Renal scattered tubular-like cells confer protective effects in the stenotic murine kidney mediated by release of extracellular vesicles
X Zou, SH Kwon, K Jiang, CM Ferguson, AS Puranik… - Scientific reports, 2018 - nature.com
To test the hypothesis that intrinsic renal scattered tubular cells (STC-like cells) contribute to
repairing injured tubular epithelial cells (TEC) by releasing extracellular vesicle (EV). EV …
repairing injured tubular epithelial cells (TEC) by releasing extracellular vesicle (EV). EV …
Stent revascularization restores cortical blood flow and reverses tissue hypoxia in atherosclerotic renal artery stenosis but fails to reverse inflammatory pathways or …
Background—Atherosclerotic renal artery stenosis (ARAS) is known to reduce renal blood
flow, glomerular filtration rate (GFR) and amplify kidney hypoxia, but the relationships …
flow, glomerular filtration rate (GFR) and amplify kidney hypoxia, but the relationships …
Management of atherosclerotic renovascular disease after Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL)
SMS Herrmann, A Saad… - Nephrology Dialysis …, 2015 - academic.oup.com
Many patients with occlusive atherosclerotic renovascular disease (ARVD) may be
managed effectively with medical therapy for several years without endovascular stenting …
managed effectively with medical therapy for several years without endovascular stenting …
Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension
A Eirin, B Ebrahimi, SH Kwon, JA Fiala… - Journal of the …, 2016 - Am Heart Assoc
Background Renovascular hypertension (RVH) impairs cardiac structure and left ventricular
(LV) function, but whether mitochondrial injury is implicated in RVH‐induced myocardial …
(LV) function, but whether mitochondrial injury is implicated in RVH‐induced myocardial …
Paradigm shifts in atherosclerotic renovascular disease: where are we now?
SC Textor, LO Lerman - Journal of the American Society of …, 2015 - journals.lww.com
Results of recent clinical trials and experimental studies indicate that whereas
atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue …
atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue …
[HTML][HTML] Oxidative stress and mitochondrial abnormalities contribute to decreased endothelial nitric oxide synthase expression and renal disease progression in early …
AS Kahveci, TT Barnatan, A Kahveci, AE Adrian… - International journal of …, 2020 - mdpi.com
Vascular abnormalities are the most important non-cystic complications in Polycystic Kidney
Disease (PKD) and contribute to renal disease progression. Endothelial dysfunction and …
Disease (PKD) and contribute to renal disease progression. Endothelial dysfunction and …