Mitochondria: a pathogenic paradigm in hypertensive renal disease

A Eirin, A Lerman, LO Lerman - Hypertension, 2015 - Am Heart Assoc
Eirin et al Mitochondria in Hypertension 265 dysmotility. 20 Hypertrophic cardiomyopathy in
Leigh's syndrome results from mutations in the mitochondrial ATPase-6 gene. 21 Likewise …

Rationale and design of the EMBRACE STEMI study: a phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of …

AK Chakrabarti, K Feeney, C Abueg, DA Brown… - American heart …, 2013 - Elsevier
BACKGROUND: Although significant efforts have been made to improve ST-segment
elevation myocardial infarction (STEMI) outcomes by reducing symptom-onset-to …

Kidney intrinsic mechanisms as novel targets in renovascular hypertension

A Eirin, AR Chade, LO Lerman - Hypertension, 2024 - Am Heart Assoc
Almost a hundred years have passed since obstruction of the renal artery has been
recognized to raise blood pressure. By now chronic renovascular disease (RVD) due to …

Renal ischemia induces epigenetic changes in apoptotic, proteolytic, and mitochondrial genes in swine scattered tubular-like cells

KS Rajagopalan, LM Glasstetter, XY Zhu, R Thaler… - Cells, 2022 - mdpi.com
Background: Scattered tubular-like cells (STCs) are dedifferentiated renal tubular cells
endowed with progenitor-like characteristics to repair injured parenchymal cells. STCs may …

[HTML][HTML] Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney

A Eirin, CM Ferguson, XY Zhu, IM Saadiq, H Tang… - Stem cell …, 2020 - Elsevier
Aims Mesenchymal stromal/stem cell (MSC)-derived extracellular vesicles (EVs) shuttle
select MSC contents and are endowed with an ability to repair ischemic tissues. We …

Atherosclerotic-nephropathy: an updated narrative review

M Simeoni, S Borrelli, C Garofalo, G Fuiano… - Journal of …, 2021 - Springer
The increased prevalence of chronic kidney disease (CKD) in elderly patients recognizes,
as main cause, the long-term exposure to atherosclerosis and hypertension. Chronic …

Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria

LH Zhang, XY Zhu, A Eirin… - American Journal …, 2019 - journals.physiology.org
Metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration,
accelerating chronic renal failure. The potential involvement of podocyte damage in early …

Rapid identification of ischemic injury in renal tissue by mass-spectrometry imaging

TC Van Smaalen, SR Ellis, NE Mascini… - Analytical …, 2019 - ACS Publications
The increasing analytical speed of mass-spectrometry imaging (MSI) has led to growing
interest in the medical field. Acute kidney injury is a severe disease with high morbidity and …

Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney

HH Szeto, S Liu, Y Soong… - American Journal of …, 2015 - journals.physiology.org
Ischemia time during partial nephrectomy is strongly associated with acute and chronic renal
injury. ATP depletion during warm ischemia inhibits ATP-dependent processes, resulting in …

Obesity‐induced mitochondrial dysfunction in porcine adipose tissue‐derived mesenchymal stem cells

Y Meng, A Eirin, XY Zhu, H Tang… - Journal of cellular …, 2018 - Wiley Online Library
Transplantation of autologous mesenchymal stem cells (MSCs) may be a viable option for
treatment of several diseases. MSCs efficacy depends on adequate function of their …