Abstract Purpose of Review This review summarizes literature pertaining to the dawning
field of therapeutic targeting of mitochondria in hypertension and discusses the potential of …

Background: Renovascular hypertension (RVHT) increases cardiovascular morbidity and
mortality. Renal revascularization with percutaneous transluminal renal angioplasty and …

Aims Patients with renovascular hypertension (RVH) exhibit elevated urinary mt DNA copy
numbers, considered to constitute surrogate markers of renal mitochondrial injury. The …

Current research on hypertension utilizes more than fifty animal models that rely mainly on
stable increases in systolic blood pressure. In experimental hypertension, grading or scoring …

The metabolic syndrome (MetS) is associated with nutrient surplus and kidney
hyperfiltration, accelerating chronic renal failure. Mitochondria can be overwhelmed by …

Over the past decade, mitochondrial dysfunction has been investigated as a key contributor
to acute and chronic kidney disease. However, the precise molecular mechanisms linking …

Microvascular rarefaction distal to renal artery stenosis is linked to renal dysfunction and
poor outcomes. Low–energy shockwave therapy stimulates angiogenesis, but the effect on …

Percutaneous transluminal renal angioplasty (PTRA) may improve cardiac function in
renovascular hypertension (RVH), but its effect on the biological mechanisms implicated in …

Evidence for an intracellular renin-angiotensin system (RAS) in various cell organelles now
includes the endoplasmic reticulum, nucleus, and mitochondria (Mito). Indeed, angiotensin …

Pericytes are considered reparative mesenchymal stem cell-like cells, but their ability to
ameliorate chronic ischemic kidney injury is unknown. We hypothesized that pericytes would …