Atherosclerotic renal artery stenosis (ARAS) remains a major cause of secondary
hypertension and kidney failure. Randomized prospective trials show that medical treatment …

Objective: Renovascular disease (RVD) produces chronic underperfusion of the renal
parenchyma and progressive ischemic injury. Metabolic abnormalities often accompany …

Renovascular disease (RVD) remains a common etiology of secondary hypertension.
Recent clinical trials revealed unsatisfactory therapeutic outcomes of renal …

Renal artery stenosis remains an important contributor to renal failure in the elderly
population, but uncertainty continues to surround the mechanisms underlying progressive …

Mitochondrial permeability transition pore (mPTP) is an important regulator in cell apoptosis
and necrosis. However, its role in hepatic steatosis, especially its electrophysiological …

New Findings What is the central question of this study? We hypothesized that chronic
mitoprotection would decrease renal vascular remodelling and dysfunction in swine …

Background Cardiac arrest is one of the leading causes of death with a very high mortality
rate. No therapeutic drug that can be administered during resuscitation has been reported …

Metabolic syndrome (MetS) leads to cardiac vascular injury, which may reflect in increased
retention of endothelial progenitor cells (EPCs). Coronary endothelial cell (EC) mitochondria …

The hyperfiltration theory has been used to explain the mechanism of low birth weight (LBW)-
related nephropathy. However, the molecular changes in the kidney proteome have not …

Background: Revascularization does not restore renal function in most patients with
atherosclerotic renal artery stenosis (RAS), likely because of inflammation and fibrosis within …