Poststroke seizure and epilepsy: a review of incidence, risk factors, diagnosis, pathophysiology, and pharmacological therapies

J Phan, M Ramos, T Soares… - Oxidative medicine and …, 2022 - Wiley Online Library
Stroke is the most common cause of epilepsy and ultimately leads to a decrease in the
quality of life of those affected. Ischemic and hemorrhagic strokes can both lead to …

Drug-resistant epilepsy: definition, pathophysiology, and management

B Mesraoua, F Brigo, S Lattanzi, B Abou-Khalil… - Journal of the …, 2023 - Elsevier
There are currently> 51 million people with epilepsy (PWE) in the world and every year> 4.9
million people develop new-onset epilepsy. The cornerstone of treatment in PWE is drug …

Systemic inflammatory response index and futile recanalization in patients with ischemic stroke undergoing endovascular treatment

S Lattanzi, D Norata, AA Divani, M Di Napoli, S Broggi… - Brain Sciences, 2021 - mdpi.com
Futile recanalization remains a significant challenge for endovascular treatment (EVT) of
acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct …

Neutrophil-to-lymphocyte ratio predicts early neurological deterioration after endovascular treatment in patients with ischemic stroke

S Lattanzi, D Norata, S Broggi, S Meletti, M Świtońska… - Life, 2022 - mdpi.com
The worsening of neurological status that occurs early after acute ischemic stroke (AIS)
remains a serious issue, and the inflammatory response plays a key role in stroke …

Antiseizure medications for post‐stroke epilepsy: a real‐world prospective cohort study

T Tanaka, K Fukuma, S Abe, S Matsubara… - Brain and …, 2021 - Wiley Online Library
Background and purpose The management of post‐stroke epilepsy (PSE) should ideally
include prevention of both seizure and adverse effects; however, an optimal antiseizure …

Latency of poststroke epilepsy can predict drug resistance

S Lattanzi, E Trinka, G Turcato, C Rinaldi… - European Journal of …, 2022 - Wiley Online Library
Abstract Background and Purpose The progressive nature of epileptogenesis raises the
question of whether the latent period may already carry information about the characteristics …

Impact of seizure recurrence on 1-year functional outcome and mortality in patients with poststroke epilepsy

H Yoshimura, T Tanaka, K Fukuma, S Matsubara… - Neurology, 2022 - AAN Enterprises
Background and Objectives The functional outcome and mortality of patients with poststroke
epilepsy (PSE) have not been assessed in a prospective study. Previous reports have …

Interictal epileptiform discharges as a predictive biomarker for recurrence of poststroke epilepsy

S Abe, T Tanaka, K Fukuma, S Matsubara… - Brain …, 2022 - academic.oup.com
Poststroke epilepsy is a major ischaemic/haemorrhagic stroke complication. Seizure
recurrence risk estimation and early therapeutic intervention are critical, given the …

Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate

MJ Koepp, E Trinka, YH Mah, C Bentes… - Epilepsia …, 2023 - Wiley Online Library
There is currently no evidence to support the use of antiseizure medications to prevent
unprovoked seizures following stroke. Experimental animal models suggested a potential …

Post-stroke epilepsy: From clinical predictors to possible mechanisms

S Freiman, WA Hauser, F Rider, N Gulyaeva… - Epilepsy Research, 2023 - Elsevier
Background Stroke is the most common cause of newly diagnosed epilepsy in the elderly,
ahead of degenerative disorders, brain tumors, and head trauma. Stroke accounts for 30 …