The pivotal role of the placenta in normal and pathological pregnancies: a focus on preeclampsia, fetal growth restriction, and maternal chronic venous disease

MA Ortega, O Fraile-Martínez, C García-Montero… - Cells, 2022 - mdpi.com
The placenta is a central structure in pregnancy and has pleiotropic functions. This organ
grows incredibly rapidly during this period, acting as a mastermind behind different fetal and …

Pathogenesis, diagnosis and management of obstetric antiphospholipid syndrome: a comprehensive review

J Alijotas-Reig, E Esteve-Valverde… - Journal of clinical …, 2022 - mdpi.com
Antiphospholipid syndrome is an autoimmune disorder characterized by vascular
thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibody …

Cardiovascular risk factors mediate the long-term maternal risk associated with hypertensive disorders of pregnancy

JJ Stuart, LJ Tanz, EB Rimm, D Spiegelman… - Journal of the American …, 2022 - jacc.org
Background Hypertensive disorders of pregnancy (HDP), including gestational hypertension
and preeclampsia, are associated with an increased risk of CVD. Objectives The purpose of …

Polygenic prediction of preeclampsia and gestational hypertension

MC Honigberg, B Truong, RR Khan, B Xiao, L Bhatta… - Nature medicine, 2023 - nature.com
Preeclampsia and gestational hypertension are common pregnancy complications
associated with adverse maternal and child outcomes. Current tools for prediction …

CCL2: An important cytokine in normal and pathological pregnancies: A review

Z Lin, JL Shi, M Chen, ZM Zheng, MQ Li… - Frontiers in …, 2023 - frontiersin.org
CC motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an
integral chemotactic factor which recruits macrophages for the immune response. Together …

Iron metabolism and ferroptosis in physiological and pathological pregnancy

Y Zhang, Y Lu, L Jin - International Journal of Molecular Sciences, 2022 - mdpi.com
Iron is a vital element in nearly every living organism. During pregnancy, optimal iron
concentration is essential for both maternal health and fetal development. As the barrier …

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome‐Induced Pyroptosis via Inhibiting the TLR4/NF‐κB/PFKFB3 Signaling in …

Y Zhang, W Liu, Y Zhong, Q Li, M Wu… - Oxidative Medicine …, 2021 - Wiley Online Library
NOD‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome‐
mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with …

Pathophysiology and risk factors of peripartum cardiomyopathy

MF Hoes, Z Arany, J Bauersachs… - Nature Reviews …, 2022 - nature.com
Peripartum cardiomyopathy (PPCM) is a potentially fatal form of idiopathic heart failure with
variable prevalence across different countries and ethnic groups. The cause of PPCM is …

NLRP3 activation and its relationship to endothelial dysfunction and oxidative stress: implications for preeclampsia and pharmacological interventions

PR Nunes, SV Mattioli, VC Sandrim - Cells, 2021 - mdpi.com
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main
causes of maternal death. Persistent inflammation in the endothelium stimulates the …

The role of peroxisome proliferator-activated receptors in preeclampsia

I Psilopatis, K Vrettou, FN Fleckenstein, S Theocharis - Cells, 2023 - mdpi.com
Preeclampsia is a common pregnancy-related hypertensive disorder. Often presenting as
preexisting or new-onset hypertension complicated by proteinuria and/or end-organ …