Bone fragility in diabetes: novel concepts and clinical implications
Increased fracture risk represents an emerging and severe complication of diabetes. The
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …
Adipose tissue inflammation and metabolic dysfunction in obesity
T Kawai, MV Autieri, R Scalia - American Journal of …, 2021 - journals.physiology.org
Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …
Obesity and bone: a complex relationship
G Rinonapoli, V Pace, C Ruggiero, P Ceccarini… - International journal of …, 2021 - mdpi.com
There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …
conclude from this review is that the increase in body weight causes an increase in BMD …
Obesity may accelerate the aging process
V Salvestrini, C Sell, A Lorenzini - Frontiers in endocrinology, 2019 - frontiersin.org
Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …
accompanied by increased disability rate. The expanded lifespan of the aging population …
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
Skeletal aging is a complex process, characterized by a decrease in bone formation, an
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …
The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis
J Li, X Chen, L Lu, X Yu - Cytokine & growth factor reviews, 2020 - Elsevier
Postmenopausal osteoporosis (PMOP) is a prevalent skeletal disorder associated with
menopause-related estrogen withdrawal. PMOP is characterized by low bone mass …
menopause-related estrogen withdrawal. PMOP is characterized by low bone mass …
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
Cellular senescence plays an important role in human diseases, including osteoporosis and
osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory …
osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory …
Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis
Epididymal white adipose tissue (eWAT) secretes an array of cytokines to regulate the
metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on …
metabolism of organs and tissues in high-fat diet (HFD)-induced obesity, but its effects on …