Emerging insights into the role of epigenetics and gut microbiome in the pathogenesis of Graves' ophthalmopathy

Y Wang, XM Ma, X Wang, X Sun, LJ Wang… - Frontiers in …, 2022 - frontiersin.org
Graves' Ophthalmopathy (GO) is an organ-specific autoimmune disease that is often
characterized by infiltration of orbital tissues and is considered as the most common extra …

Nature vs. nurture: FOXP3, genetics, and tissue environment shape Treg function

A Raugh, D Allard, M Bettini - Frontiers in Immunology, 2022 - frontiersin.org
The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well
established; however, the precise alterations in Treg function in autoimmune individuals and …

Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases

X Chen, Y Gao, J Xie, H Hua, C Pan, J Huang… - Journal of Translational …, 2023 - Springer
Background The incidence of pediatric inflammatory bowel disease (PIBD) has been
steadily increasing globally. Delayed diagnosis of PIBD increases the risk of complications …

IBD-associated Atg16L1T300A polymorphism regulates commensal microbiota of the intestine

H Liu, P Gao, B Jia, N Lu, B Zhu, F Zhang - Frontiers in immunology, 2022 - frontiersin.org
The development of inflammatory bowel disease (IBD) is driven by the interaction among
host genetics, microbiota, and the immune system of the entire digestive tract …

Identifying microbiome dynamics in pediatric IBD: More than a family matter

N Dovrolis, A Moschoviti, S Fessatou, G Karamanolis… - Biomedicines, 2023 - mdpi.com
Background: Pediatric inflammatory bowel disease (IBD) is a chronic inflammatory intestinal
disease that affects both children and adolescents. Symptoms can significantly affect a …

[HTML][HTML] Long non-coding RNA ANRIL serves as a potential marker of disease risk, inflammation, and disease activity of pediatric inflammatory bowel disease

H Xia, S Li, Y He, Q Ren, S Qin - Clinics and Research in Hepatology and …, 2022 - Elsevier
Background Long non-coding antisense RNAs in the INK4 locus (lnc-ANRIL) have been
reported to be involved in inflammation and immunity. However, few studies have reported …

Pediatric management of Crohn's disease

EB Mitchel, JR Rosh - Gastroenterology Clinics, 2022 - gastro.theclinics.com
Twenty-five percent of individuals with inflammatory bowel disease (IBD) are diagnosed
before 18 years of age and are considered to have pediatric-onset IBD. 1, 2 Recent studies …

[HTML][HTML] Risk of venous thromboembolism in children and adolescents with inflammatory bowel disease: A systematic review and meta-analysis

XY Zhang, HC Dong, WF Wang… - World Journal of …, 2022 - ncbi.nlm.nih.gov
BACKGROUND A two-to three-fold increased risk of venous thrombotic events (VTE) has
been demonstrated in patients with inflammatory bowel disease (IBD) compared to the …

Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood

A Sălcudean, AG Nan, CR Bodo, MC Cosma, EG Strete… - Diagnostics, 2023 - mdpi.com
Inflammatory bowel disease (IBD), which includes Crohn's disease, ulcerative colitis, and
unspecified inflammatory bowel disease, is a chronic, unpredictable and immune-mediated …

A current state of proteomics in adult and pediatric inflammatory bowel diseases: a systematic search and review

O Fabian, L Bajer, P Drastich, K Harant… - International Journal of …, 2023 - mdpi.com
Inflammatory bowel diseases (IBD) are systemic immune-mediated conditions with
predilection for the gastrointestinal tract and include Crohn's disease and ulcerative colitis …