Rapid advances in high-throughput sequencing and a growing realization of the importance
of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies …

BRCA1 and BRCA2 are important breast and ovarian cancer susceptibility genes, and
mutations in these two genes confer lifetime risks of breast cancer of up to 80% and ovarian …

Cancer has long been understood as a somatic evolutionary process, but many details of
tumor progression remain elusive. Here, we present BitPhylogeny, a probabilistic framework …

Phylogenetics is a powerful approach in finding evolution of current day species. By
studying phylogenetic trees, scientists gain a better understanding of how species have …

Oncogenetic graphical models are crucial for understanding cancer progression by
analyzing the accumulation of genetic events. These models are used to identify statistical …

Unraveling molecular regulatory networks underlying disease progression is critically
important for understanding disease mechanisms and identifying drug targets. The existing …

Background While in principle a seemingly infinite variety of combinations of mutations
could result in tumor development, in practice it appears that most human cancers fall into a …

Despite decades of research and an enormity of resultant data, cancer remains a significant
public health problem. New tools and fresh perspectives are needed to obtain fundamental …

The evolutionary dynamics of cancer, characterized by its profound heterogeneity, demand
sophisticated tools for a holistic understanding. This review delves into tumor phylogenetics …

In biological systems that undergo processes such as differentiation, a clear concept of
progression exists. We present a novel computational approach, called Sample Progression …