Cancer immunotherapy by immune checkpoint blockade has proven its great potential by
saving the lives of a proportion of late stage patients with immunogenic tumor types …

Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

The emergence of immuno-oncology as the first broadly successful strategy for metastatic
cancer will require clinicians to integrate this new pillar of medicine with chemotherapy …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

The nature and extent of immune cell infiltration into solid tumours are key determinants of
therapeutic response. Here, using a DNA methylation-based approach to tumour cell …

The tumor microenvironment restrains conventional T cell (Tconv) activation while facilitating
the expansion of Tregs. Here we showed that Tregs' advantage in the tumor milieu relies on …

The three-signal paradigm tries to capture how the innate immune system instructs adaptive
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …

CD4+ Foxp3+ regulatory T-cells (Tregs) are a unique subset of helper T-cells, which
regulate immune response and establish peripheral tolerance. Tregs not only maintain the …

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their
presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in …

Cytokines activate or inhibit immune cell behavior and are thus integral to all immune
responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream …