The tumor microenvironment (TME) enhances regulatory T (Treg) cell stability and
immunosuppressive functions through up-regulation of lineage transcription factor Foxp3, a …

Talimogene laherparepvec (T-VEC) is a genetically modified herpes simplex 1 virus (HSV-1)
approved for cancer therapy. We investigate its effect on the clinical, histological, single-cell …

Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent
kinase 4 (CDK4) and CDK6, have attracted considerable interest as potential targets for …

FoxP3+ T regulatory (Treg) cells are central elements of immunologic tolerance. They are
abundant in many tumors, where they restrict potentially favorable antitumor responses. We …

Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal
tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human …

Tregs have a role in immunological tolerance and immune homeostasis by suppressing
immune reactions, and its therapeutic potential is critical in autoimmune diseases and …

Background Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune
checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been …

Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most
cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly …

A major challenge faced by epigenome-wide association studies (EWAS) is cell-type
heterogeneity. As many EWAS have already demonstrated, adjusting for changes in cell …

Surgical resection continues to be the mainstay treatment for solid cancers even though
chemotherapy and immunotherapy have significantly improved patient overall survival and …