ABSTRACT Building the Tree of Life (ToL) is a major challenge of modern biology, requiring
advances in cyberinfrastructure, data collection, theory, and more. Here, we argue that …

Compression as an accelerant of computation is increasingly recognized as an important
component in engineering fast real-world machine learning methods for big data; cf, its …

Next-generation sequencing has gained increasing importance in the clinical application in
the determination of genetic variants. In the pre-implantation genetic test, this technique has …

Genomic copy number variations (CNVs) are considered as a significant source of genetic
diversity and widely involved in gene expression and regulatory mechanism, genetic …

Identifying regions of the genome under selection is an ongoing effort in population genetics
and quantitative biology. Selection creates signals within the genome that can be detected …

Abstract Background Full Bayesian inference for detecting copy number variants (CNV) from
whole-genome sequencing (WGS) data is still largely infeasible due to computational …

CNV detection requires a high-quality segmentation of genomic data. In many WGS
experiments, sample and control are sequenced together in a multiplexed fashion using …

Living organisms are complex systems of interacting components. A crucial step to
understand those complex biological systems is the construction of biological networks that …