Integration of electrochemical interface and cell-free synthetic biology for biosensing

P Yu, C Lei, Z Nie - Journal of Electroanalytical Chemistry, 2022 - Elsevier
With increasing concerns about health, safety, and environmental issues, the development
of sensitive, reliable and efficient biosensing technologies for the early detection of disease …

Assembly of functional microbial ecosystems: from molecular circuits to communities

S Wu, Y Zhou, L Dai, A Yang… - FEMS Microbiology …, 2024 - academic.oup.com
Microbes compete and cooperate with each other via a variety of chemicals and circuits.
Recently, to decipher, simulate or reconstruct microbial communities, many researches have …

RNA engineering for public health: innovations in RNA-based diagnostics and therapeutics

W Thavarajah, LM Hertz, DZ Bushhouse… - Annual review of …, 2021 - annualreviews.org
RNA is essential for cellular function: From sensing intra-and extracellular signals to
controlling gene expression, RNA mediates a diverse and expansive list of molecular …

合成生物学在下一代基因诊断技术中的应用进展

吕海龙, 王建, 吕浩, 王金, 徐勇, 顾大勇 - 合成生物学, 2023 - synbioj.cip.com.cn
近年来, 合成生物学技术取得了飞速的发展, 与此同时也极大地推动了基因诊断领域的技术革新
和应用拓展. 准确诊断疾病和监测治疗后反应的检测方法对有效的临床管理至关重要 …

Synthetic protein circuits for programmable control of mammalian cell death

S Xia, AC Lu, V Tobin, K Luo, L Moeller, DJ Shon, R Du… - Cell, 2024 - cell.com
Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate
harmful cells and modulate the immune system by dampening or stimulating inflammation …

Electrochemical biosensing interfaced with cell-free synthetic biology

B Wang, J Zhao, J Zhang, T Wei, K Han… - TrAC Trends in Analytical …, 2024 - Elsevier
Synthetic biology's multiscale approaches to biosensing facilitate biological detection across
diverse environments, leading to the development of advanced bio/electronic devices that …

Gigavalent display of proteins on monodisperse polyacrylamide hydrogels as a versatile modular platform for functional assays and protein engineering

T Fryer, JD Rogers, C Mellor, TN Kohler… - ACS Central …, 2022 - ACS Publications
The assembly of robust, modular biological components into complex functional systems is
central to synthetic biology. Here, we apply modular “plug and play” design principles to a …

Multicellular pd control in microbial consortia

V Martinelli, D Salzano, D Fiore… - IEEE Control Systems …, 2023 - ieeexplore.ieee.org
We propose a multicellular implementation of a biomolecular PD feedback controller to
regulate gene expression in a microbial consortium. The implementation involves …

合成生物学在疾病诊疗中的应用

吴晓昊, 廖荣东, 李飞云, 欧阳中天, 冉怡, 公维远… - 合成生物学, 2023 - synbioj.cip.com.cn
合成生物学是一门新兴学科. 从广义上讲, 合成生物学是通过将基因工程, 系统生物学,
计算机工程等多学科作为工具, 根据特定需求进行设计, 乃至重新合成生物体系. 近20 年来 …

Electrochemiluminescence Biosensor for Ascorbic Acid Based on Target Transformation of Cell-Free RNA Transcription System and Duplex-Specific Nuclease …

M Chen, H Zeng, F Luo, Y Huang, C Lin… - Analytical …, 2024 - ACS Publications
A cell-free RNA transcription system had been coupled with electrochemiluminescence
(ECL) detection technology for the first time to develop an ascorbic acid (AA, acting as a …