5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

After a series of serendipitous discoveries of pharmacological treatments for mania and
depression several decades ago, relatively little progress has been made for novel …

Selective serotonin reuptake inhibitors (SSRIs) display a delayed onset of action of several
weeks. Past work in naive rats showed that 5-HT 4 receptor agonists had rapid effects on …

Selective serotonin reuptake inhibitors are the mostly widely used treatment for major
depressive disorders and also are prescribed for several anxiety disorders. However, similar …

Major depressive disorder (MDD) is a severe psychiatric syndrome with high prevalence
and socioeconomic impact. Current antidepressant treatments are based on the blockade of …

Germ cells are vulnerable to stress. Therefore, how organisms protect their future progeny
from damage in a fluctuating environment is a fundamental question in biology. We show …

The work described herein aims at finding new potential ligands for the brain imaging of 5-
HT4 receptors (5-HT4Rs) using single-photon emission computed tomography (SPECT) …

Serotonin (5-HT) 3 receptors are the only ligand-gated ion channel of the 5-HT receptors
family. They are present both in the peripheral and central nervous system and are localized …

Major depression is a heterogeneous disorder, both in terms of symptoms, ranging from
anhedonia to cognitive impairment, and in terms of pathogenesis, with many interacting …

5-HT4 receptors control brain physiological functions such as learning and memory, feeding
and mood behaviour as well as gastro-intestinal transit. 5-HT4 receptors are one of the 5-HT …