Oxidative stress plays an important role in the pathogenesis of chronic obstructive
pulmonary disease (COPD) caused by cigarette smoke and characterized by chronic …

Abstract The mammalian Transient Receptor Potential Canonical (TRPC) subfamily
comprises seven transmembrane proteins (TRPC1–7) forming cation channels in the …

Background Skeletal muscle mass and function losses in aging individuals are associated
with quality of life deterioration and disability. Mesenchymal stromal cells exert …

Gene mutations causing loss of dystrophin result in the severe muscle disease known as
Duchenne muscular dystrophy (DMD). Despite efforts at genetic repair, DMD therapy …

Mechanosensitive channels (MS channels) are membrane proteins capable of responding
to mechanical stress over a wide dynamic range of external mechanical stimuli. In recent …

Transient receptor potential canonical 6 (TRPC6) channel is an important non-selective
cation channel with a variety of physiological roles in the central nervous system. Evidence …

Introduction Ulcerative colitis (UC) is an incurable and highly complex chronic inflammatory
bowel disease (IBD) affecting millions of people worldwide. C-phycocyanin (C-PC) has been …

Pancreatic ductal adenocarcinoma is a devastating disease with a dismal prognosis.
Therapeutic interventions are largely ineffective. A better understanding of the …

Allergic asthma is a chronic inflammatory disease in which oxidative stress serves a pivotal
role. In clinical practice, dexmedetomidine (DEX), an α-2-adrenergic receptor agonist, is …

Cystic fibrosis (CF) is an autosomal recessive disorder characterized by mutations in the
cystic fibrosis transmembrane conductance regulator gene, which causes multifunctional …