Following a diagnosis of breast cancer, the most immediate challenges in patient
management are the determination of prognosis and identification of the most appropriate …

Breast cancer (BC) is the most frequently occurring malignancy in women worldwide.
Despite the substantial advancement in understanding the molecular mechanisms and …

Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …

Early studies have shown how aberrantly expressed microRNAs are a hallmark of several
diseases like cancer. MicroRNA expression profiling was shown to be associated with …

Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

Cancer is a systemic disease encompassing multiple components of both tumor cells
themselves and host stromal cells. It is now clear that stromal cells in the tumor …

Background Current staging methods do not accurately predict the risk of disease
recurrence and benefit of adjuvant chemotherapy for patients who have had surgery for …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Breast cancer affects approximately 12% women worldwide and results in 14% of all cancer-
related fatalities. Breast cancer is commonly categorized into one of four main subtypes …

MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that
posttranscriptionally regulate gene expression by targeting their corresponding messenger …