Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

Proteasomes are multisubunit complexes that catalyze the majority of protein degradation in
mammalian cells to maintain protein homeostasis and influence the regulation of most …

The proteasome is responsible for mediating intracellular protein degradation and
regulating cellular function with impact on tumor and immune effector cell biology. The …

PA28 (also known as 11S, REG or PSME) is a family of proteasome regulators whose
members are widely present in many of the eukaryotic supergroups. In jawed vertebrates …

Pediatric high-grade gliomas, specifically diffuse midline gliomas, account for only 20% of
clinical cases but are 100% fatal. A majority of the DMG cases are characterized by the …

Cumulative evidence indicates that excessive consumption of calories from saturated fat
contributes to the development of Alzheimer's disease (AD). Here, we assess the triggering …

Aberrant α-synuclein (α-Syn) accumulation resulting from proteasome dysfunction is
considered as a prominent factor to initiate and aggravate the neurodegeneration in …

To increase the number of cancer patients that can be treated with T cell receptor (TCR)
gene therapy, we aimed to identify a set of high-affinity cancer-specific TCRs targeting …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …