Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known
chemotherapeutic drug. It has been used for treatment of numerous human cancers …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

Translocator protein (TSPO) is an 18kDa high affinity cholesterol-and drug-binding protein
found primarily in the outer mitochondrial membrane. Although TSPO is found in many …

Limited information is available concerning the expression and role of microRNAs in
prostate cancer. In this study, we investigated the involvement of miR-205 in prostate …

Autophagy is a process of self-degradation that maintains cellular viability during periods of
metabolic stress. Although autophagy is considered a survival mechanism when faced with …

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men.
Hormone-refractory invasive PCa is the end stage and accounts for the majority of PCa …

Protein kinase Cδ (PKCδ) is a member of the PKC family that plays a critical role in the
regulation of various cellular processes, including cell proliferation, cell death, and tumor …