Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial …

M Terzolo, M Fassnacht, P Perotti, R Libé… - The Lancet Diabetes & …, 2023 - thelancet.com
Background Adjuvant treatment with mitotane is commonly used after resection of
adrenocortical carcinoma; however, treatment remains controversial, particularly if risk of …

Pregnancy in patients with adrenocortical carcinoma: a case-based discussion

S Puglisi, V Basile, P Sperone, M Terzolo - Reviews in Endocrine and …, 2023 - Springer
Although adrenocortical carcinoma (ACC) during pregnancy is rare, a retrospective review
of a case series at our hospital revealed that almost one third of our patients were women in …

The management of postoperative disease recurrence in patients with adrenocortical carcinoma: a retrospective study in 106 patients

A Calabrese, S Puglisi, C Borin, V Basile… - European Journal of …, 2023 - academic.oup.com
Objective The management of adrenocortical carcinoma (ACC) recurrences remains
controversial, and we present herein our experience with postoperative ACC recurrences …

[HTML][HTML] Взаимосвязь стероидного метаболома мочи с течением адренокортикального рака

ЛИ Великанова, НВ Ворохобина… - Альманах …, 2023 - cyberleninka.ru
Обоснование. Адренокортикальный рак (АКР)–редкое заболевание,
характеризующееся агрессивным течением и быстрым метастазированием. Для …

Radiopharmaceuticals for treatment of adrenocortical carcinoma

K Michalski, W Schlötelburg, PE Hartrampf, A Kosmala… - Pharmaceuticals, 2023 - mdpi.com
Adrenocortical carcinoma (ACC) represents a rare tumor entity with limited treatment options
and usually rapid tumor progression in case of metastatic disease. As further treatment …

Recovery of adrenal function after stopping mitotane in patients with adrenocortical carcinoma

B Altieri, O Kimpel, F Megerle… - European Journal of …, 2024 - academic.oup.com
Objective Mitotane is the standard therapy of adrenocortical carcinoma (ACC) due to its
relative selectivity of its cytotoxic effects toward adrenocortical cells. Therefore, it virtually …

Construction and validation of a prognostic model for predicting overall survival of primary adrenal malignant tumor patients: a population-based study with 1,080 …

W Xie, Y Zhang, R Cao - Frontiers in Surgery, 2022 - frontiersin.org
Objective Primary adrenal malignant tumor is rare. The factors affecting the prognosis
remain poorly defined. This study targeted to construct and corroborate a model for …

Albumin/Mitotane Interaction Affects Drug Activity in Adrenocortical Carcinoma Cells: Smoke and Mirrors on Mitotane Effect with Possible Implications for Patients' …

A Schiavon, L Saba, G Catucci, J Petiti… - International Journal of …, 2023 - mdpi.com
Background: Mitotane is the only drug approved for the treatment of adrenocortical
carcinoma (ACC). Although it has been used for many years, its mechanism of action …

[HTML][HTML] A Revised Version of the TNM Classification Leads to Optimized Predictive Performance in Patients with Adrenocortical Carcinoma

SO David, S Krieg, I Esposito, M Schott… - Hormone and …, 2023 - thieme-connect.com
The prognostic stratification of the current AJCC/UICC TNM classification for adrenocortical
carcinoma (ACC) has been validated in only a few studies. In this study, it was hypothesized …

Efficacy and safety of radiation therapy in advanced adrenocortical carcinoma

O Kimpel, P Schindler, L Schmidt-Pennington… - British Journal of …, 2023 - nature.com
Background International guidelines emphasise the role of radiotherapy (RT) for the
management of advanced adrenocortical carcinoma (ACC). However, the evidence for this …